连续性肾脏替代疗法治疗重症急性胰腺炎效果分析  

Analysis of effect of continuous renal replacement therapy in treatment of severe acut pancreatitis

作　　者：许国斌[1] 张近波[1] 董美平[1] 朱金强[1] 史朝红[1] 鄢来超[1] 曹烈祥[1] 吴仙丹[1] 

机构地区：[1]温州医学院附属温岭医院温岭市第一人民医院急诊重症监护室,浙江省温岭317500

出　　处：《中国基层医药》2013年第17期2561-2563,共3页Chinese Journal of Primary Medicine and Pharmacy

基　　金：浙江省温岭市科技计划项目（2011wlcb0095）

摘　　要：目的 研究连续性肾脏替代疗法（CRRT）对重症急性胰腺炎（SAP）患者的治疗效果.方法 按照平行对照设计原理,将70例患者按数字表法随机分为对照组35例和CRRT组35例,对照组采用常规治疗,CRRT组在常规治疗基础上行CRRT治疗,比较两组临床疗效.结果 两组治疗前急性生理学及慢性健康状况评分Ⅱ（APACHEⅡ）评分、C反应蛋白（CRP）水平差异均无统计学意义；治疗后对照组、CRRT组A-PACHEⅡ评分分别为（16.85±2.01）分、（11.52 ±1.85）分,两组差异有统计学意义（t=2.176,P＜0.05）；CRP水平分别为（23.77±4.15） mg/L、（11.98±2.04） mg/L,两组差异有统计学意义（t=2.793,P＜0.01）；对照组、CRRT组ICU住院时间分别为（19.92 ±2.28）d、（12.73±1.95）d,两组差异有统计学意义（t=2.313,P＜0.05）；对照组病死率为45.1％,高于CRRT组的14.3％（Х^2=7.000,P＜0.01）.结论 在常规治疗基础上早期行CRRT治疗,能降低SAP患者的ICU住院时间,降低病死率.Objective To investigate the effect of continuous renal replacement therapy（CRRT） on severe acute pancreatitis（SAP）.Methods 70 patients with SAP were collected and divided into the control group and CRRT treatment group.The clinical data and the score of APACHE Ⅱ were compared between the two groups.Results There were no significant differences between control group and CRRT treatment group in APACHE Ⅱ score,C-reactive protein（CRP） before treatment（P 〉 0.05）.After treatment,the score of APACHE Ⅱ was significantly lower in CRRT treatment group than that in control group[（11.52 ± 1.85） points vs （16.85 ± 2.01） points,t =2.176,P 〈0.05],the level of CRP was significantly lower in CRRT treatment group than that in control group[（11.98 ±2.04）ng/L vs （23.77 ± 4.15）ng/L,t =2.793,P 〈 0.01] ;the hospitalizing time was significantly lower in CRRT treatment group than that in control group[（12.73 ± 1.95）d vs （19.92 ±2.28）d,t =2.313,P 〈0.05],the mortality rate was significantly lower in CRRT treatment group than that in control group（14.3% vs 45.1%,Х^2 =7.000,P 〈 0.01）.Conclusion CRRT could decrease both the hospitalizing time and mortality in SAP patients based on traditional treatment.

关 键 词：连续性肾替代治疗 胰腺炎 急性坏死性 

分 类 号：R576[医药卫生—消化系统]