胃癌及癌旁黏膜组织胎盘型谷胱甘肽S-转移酶的表达  

THE EXPRESSION OF PLACENTAL GLUTATHIONS S TRANSFERASE IN GASTRIC CARCINOMA AND SURROUNDING TISSUE

作　　者：殷拥军[1] 窦颖[1] 邹伟[2] 牛兆山[2] 

机构地区：[1]青岛大学医学院病理生理学教研室,青岛266021 [2]青岛大学医学院病理学教研室,青岛266021

出　　处：《青岛大学医学院学报》2000年第1期55-57,共3页Acta Academiae Medicinae Qingdao Universitatis

摘　　要：1目的　探讨胎盘型谷胱甘肽 S-转移酶 (GSTπ)在胃癌中表达的意义。 2方法　应用 L SAB免疫组化方法检测了胃癌及癌旁黏膜组织 GSTπ的表达。 3结果　正常胃黏膜组织 GSTπ阳性表达率为 16 .7% ,肠上皮化生和不典型增生腺体 GSTπ阳性表达率分别为 71.4%和 10 0 .0 % ,显著高于正常胃黏膜 (χ2 =8.4,19.4,P <0 .0 1)。胃癌组织中 GSTπ阳性表达率为 80 .3% ,高分化腺癌和低分化腺癌 GSTπ阳性表达率显著高于未分化癌和黏液腺癌 (χ2 =13.8,P<0 .0 1)。GSTπ表达与肿瘤大小、浸润深度及淋巴结转移等无关 (P>0 .0 5 )。4结论GSTπ可作为胃癌及其癌前病变的标志酶 ,对胃癌的早期诊断有辅助意义。Objective To study the value of placental glutathione S transferse( GSTπ) expression in gastric carcinoma and its surrounding tissue. Methods GSTπ was detected in gastric carcinoma and its surrounding tissue with LSAB immunohistochemistry. Results Only 16.7% nomal gastric mucosa were GSTπ positive, but 71.4% intestinal metaplasis and 100% atypical hyperplasis were GSTπ positive. The GSTπ positive rate of carcinoma was 80.3%, but in different differentiated group, there was significant difference: GSTπ positive rate of well differentiated and poor differentiated group was significantly higher than that of undifferentiated and mucuous carcinoma(χ 2=13.8,P<0.01). There was no correlation between GSTπ expression and tumor size, invasive depth, lymph node metastasis. Conclusion GSTπ is a new sensitive marker for immunohistochemical detection of gastric carcinoma and precancerous lesion, it may be valuble in the early dignosis of gastric carcinoma. [

关 键 词：胃肿瘤 免疫组织化学 GSTΠ 癌旁黏膜组织 

分 类 号：R735.2[医药卫生—肿瘤]