奥氮平对精神分裂症认知功能的疗效观察  

The effect of Olanzapine on cognitive function in schizophrenia

作　　者：蓝晓嫦[1] 钟潇琦[1] 吴逢春[1] 

机构地区：[1]广州市精神病医院,广东广州510370

出　　处：《中国民康医学》2013年第14期20-21,128,共3页Medical Journal of Chinese People’s Health

摘　　要：目的:了解奥氮平对精神分裂症患者认知功能的疗效。方法:筛查符合DSM-Ⅳ精神分裂症诊断标准的患者55例,入组后予奥氮平治疗,分别在基线期及治疗6周后评定阳性与阴性症状量表(PANSS)及认知功能,包括数字符号、数字广度(顺背、倒背)以及语义流畅性测验。比较治疗前后PANSS总分及因子分、认知功能评分。结果:治疗6周后PANSS总分、阳性症状分、阴性症状分、一般精神病理分以及语义流畅性总数、正确数均明显改善(P<0.05)。结论:奥氮平对精神分裂症认知功能障碍有改善作用。Objective：To research the efficacy of Olanzapine on cognitive function in schizophrenia. Methods：55 patients with schizophrenia who met DSM - IV were treated with Olanzapine for 6 weeks. The Positive and Negative Symptom Scale （PANSS） and Cognitive function test were used to evaluate efficacy before and at the end of 6 weeks of treatment respectively. Cognitive functions test including digital symbol, digit span test （ go back, back）, and the semantic fluency test. Compare PANSS total scores, factor score and cognitive function score before and after the treatment. Results：After 6 weeks treatment, the total scores of PANSS and positive symptoms,negative symptoms points,general psychopathology and semantic fluency were signifi- cantly improved（ P 〈 0.05 ）. Conclusion ： Olanzapine can improve cognitive dysfunction in schizophrenia.

关 键 词：精神分裂症 认知功能 奥氮平 

分 类 号：R749.3[医药卫生—神经病学与精神病学]