纳洛酮治疗新生儿缺氧缺血性脑病的临床观察  

Clinical study of treating the neonatal hypoxic ischemic encephalopathy with naloxone

作　　者：杨蕾华[1] 张辛[2] 

机构地区：[1]解放军第473医院儿科,甘肃兰州730070 [2]兰州军区兰州总医院

出　　处：《西北国防医学杂志》2000年第3期214-215,共2页Medical Journal of National Defending Forces in Northwest China

摘　　要：目的 :观察纳洛酮对新生儿缺氧缺血性脑病 (HIE)的临床疗效。方法 :将 32例HIE患儿随机分为纳洛酮治疗组 (17例 )和对照组 (15例 ) ,并行CT ,EEG和临床分度 ,分别给予纳洛酮 0 .1mg·kg-1·d-1治疗 1周和一般常规治疗。结果 :两组平均临床症状消失时间有非常显著差异 (P <0 .0 1) ,EEG好转率也有显著差异 (P <0 .0 5 )。结论 :纳洛酮对HIE的疗效明显高于一般常规治疗 ,中。Objective:[WT5BZ]To study the clinical effects of naloxone on neonatal hypoxic ischemic encephalopathy(HIE).[WT5HZ]Methods:[WT5BZ]32 neonates with HIE were divided into two groups at random:Naloxone treatment group( n =17)with naloxone 0.1 mg·kg -1 ·d -1 for one week,control group( n =15)with routine treatment.[WT5HZ]Results:[WT5BZ]There were significant differences in the average time of clinical symptoms disappearance( P <0.01)and the rate of EEG on the mend( P <0.05)between two groups.[WT5HZ]Conclusion:[WT5BZ]The clinical effect of naloxone therapy on HIE is better than that of routine therapy.The complicationes of naloxone group are fewer than that of other group. [WT5HZ]

关 键 词：缺氧缺血性脑病 纳洛酮 新生儿 药物疗法 

分 类 号：R742[医药卫生—神经病学与精神病学]