胃癌单克隆抗体临床诊断应用及与CP相关性的探讨  

The application of McAb against gastric carcinoma in clinic and the relationship with CP

作　　者：吕同德[1] 于兰[1] 陈新民[1] 曾玮[1] 贺建萍[1] 邢传平[1] 

机构地区：[1]兰州军区兰州总医院,甘肃兰州730050

出　　处：《西北国防医学杂志》2000年第3期223-224,共2页Medical Journal of National Defending Forces in Northwest China

摘　　要：目的 :研究胃癌单克隆抗体的表达及临床意义。方法 :用本室制备的对胃癌有较强特异性的McAbGMG1:1D1- 2对 15 1例内窥镜活检组织压印片进行免疫组织化学检查。结果 :用本法检查组织印片中的癌细胞以及具有癌细胞相关抗原的癌前病变组织 ,特异性强 ,反应灵敏 ,结果可靠。结论 :如果与内窥镜和常规病理学检查联合应用 ,会提高早期癌的检出率 ,本文还就抗人胃癌McAb与CP的相关性进行了初步探讨。Objective:[WT5BZ]To study the expression and clinical significance of McAb against gastric carcinoma.[WT5HZ]Methods:[WT5BZ]151 samples of print/press sections from gastric endoscope biopsy were examined by the monoclonal antibody GMG1∶1D1-2 which was specific to gastric carcinoma and made by author's laboratory.[WT5HZ]Results:[WT5BZ]The results showed that the method had a high specificity and sensitivity for examination and recognition of the gastric carcinoma cells and cells of precancerous lesions with related antigen of carcinomatous cells in print sections and the examination results was reliable.[WT5HZ]Conclusion:[WT5BZ]The method is very useful to promote the diagnosis rate of earlier lesion,especially combining the endoscopy and routine pathological examination.The relationship of McAb and CP was also discussed in this paper. [WT5HZ]

关 键 词：胃癌 单克隆抗体 诊断 幽门弯曲菌 

分 类 号：R735.2[医药卫生—肿瘤]