食管癌患者放疗后血清IGF-Ⅰ和TGF-α检测及临床意义  

Study on clinical significance in changes of serum levels of IGF-Ⅰ and TGF-α in patients with esophageal carcinoma after radiotherapy

作　　者：华克胜[1] 

机构地区：[1]山东省菏泽市立医院胸外科,山东菏泽274000

出　　处：《临床和实验医学杂志》2013年第15期1232-1233,共2页Journal of Clinical and Experimental Medicine

摘　　要：目的观察食管癌患者放疗前后血清胰岛素生长因子-Ⅰ(IGF-Ⅰ)及转化生长因子-α(TGF-α)的水平变化,并探讨其对预测转移的临床意义。方法通过放射免疫分析法测定40例食管癌患者放疗前、放疗后1个月及放疗后个6月的血清IGF-Ⅰ及TGF-α水平,并与40名正常健康人作比较。结果食管癌患者放疗前血清IGF-Ⅰ及TGF-α水平明显高于正常人(P<0.01);放疗后1个月时IGF-Ⅰ及TGF-α水平明显降低(P<0.01);放疗后6个月时,出现转移者IGF-Ⅰ及TGF-α水平明显高于未出现转移者(P<0.01)。结论血清IGF-Ⅰ及TGF-α水平检测有助于判断放疗疗效、预测转移。Objective To observe the changes in serum levels of IGF-Ⅰ and TGF-α in patients with esophageal carcinoma before and after radiotherapy,so as to explore their clinical significance for metastasis.Methods The serum levels of IGF-Ⅰ and TGF-α in 40 patients with esophageal carcinoma were detected before and after radiotherapy for one month and six months,as well as in 40 normal controls.Results In comparison with those before radiotherapy,the serum levels of IGF-Ⅰ and TGF-α were dramatically decreased in patients after radiotherapy for one month（P 0.01）.But the serum levels of IGF-Ⅰ and TGF-α after radiotherapy for six months were significantly elevated in patients with metastasis compared with those without metastasis（P 0.01）.Conclusion Detection of serum levels of IGF-Ⅰ and TGF-α is helpful in evaluation of the effect of radiotherapy and in forecast of metastasis.

关 键 词：食管癌 放疗 IGF-Ⅰ TGF-Α 

分 类 号：R735.1[医药卫生—肿瘤]