奥氮平治疗脑器质性精神障碍临床分析  

Clinical analysis on olanzapine in treatment of cerebral organic mental disorders

作　　者：陈伟[1] 聂文燕[1] 

机构地区：[1]重庆市精神卫生中心,重庆400036

出　　处：《现代医药卫生》2013年第14期2122-2122,2124,共2页Journal of Modern Medicine & Health

摘　　要：目的观察奥氮平治疗脑器质性精神障碍的疗效和不良反应。方法对脑器质性精神障碍患者33例给予奥氮平治疗4周,以简明精神病量表(BPRS)和临床疗效总评量表(CGI-SI)评定精神症状与治疗效果,用不良反应量表(TESS)评定不良反应。结果治疗后BPRS评分及CGI-SI评分较治疗前显著下降,差异有统计学意义(P<0.01)。治疗后总有效率为81.8%(27/33)。TESS评分治疗前后比较,差异无统计学意义(P>0.05)。结论奥氮平治疗脑器质性精神障碍具有较好的疗效和安全性。Objective To observe the effect and adverse reactions of olanzapine in the treatment of brain organic mental disorders.Methods 33 cases of cerebral organic mental disorders were treated with olanzapine for 4 weeks.The psychotic symp toms and the therapeutic effects were assessed by the Brief Psychiatric Rating Scale（BPRS） and the Clinical G1obal Impression Scale（CGI-SI）,and Treatment Emergent Symptom Scale（TESS） was used to evaluate the adverse reactions.Results The scores of BPRS and CGI-GI after treatment were decreased significantly than those before treatment,the difference showing statistical significance（P0.01）.The total effective rate after treatment was 81.8%（27/33）.There were no significant difference in TESS between before and after treatment（P0.05）.Conclusion Olanzapine has better effective and safety in the treatment of cerebral organic mental disorders.

关 键 词：苯二氮类 精神障碍 脑 器质性精神障碍 奥氮平 

分 类 号：R749.1[医药卫生—神经病学与精神病学]