大肠癌区域引流淋巴结中T淋巴细胞亚群的变化及意义  

Change of T cell subsets in regional draining lymph nodes in patients with colorectal cancer

作　　者：卢永刚[1,2] 刘凌云[1,2] 孙秀娟[3] 何沙[1,2] 吕一[1,2] 

机构地区：[1]广西柳州市柳铁中心医院肝胆胰外科 [2]南方医科大学附属柳州医院肝胆胰外科,广西柳州545007 [3]广西柳州市柳铁中心医院病理科,广西柳州545007

出　　处：《海南医学院学报》2013年第10期1380-1382,共3页Journal of Hainan Medical University

基　　金：广西区卫生厅自筹经费科研课题(计划课题临床类Z2010131号)~~

摘　　要：目的:探讨大肠癌区域引流淋巴结中T淋巴细胞亚群的变化及意义。方法:通过检测大肠癌区域引流淋巴结中T淋巴细胞亚群活性的表达,研究大肠癌患者区域引流淋巴结局部免疫状况与肿瘤侵袭转移的关系。结果:大肠癌区域淋巴结转移组较无淋巴结转移组、淋巴结转移组中阳性转移淋巴结较阴性者CD4+T细胞值、CD4+/CD8+比值下降,CD8+T细胞值显著升高,差异均有统计学意义(P<0.05)。结论:大肠癌区域引流淋巴结中免疫功能紊乱,可能与大肠癌侵袭转移有关。Objective：To investigate the change of T cell subsets in regional draining lymph nodes in patients with colorectal cancer.Methods：T cell subsets in regional draining lymph nodes in patients with colorectal cancer was detected by immunohistochemistry S-P method,and the relationship of local immune status and tumor invasion and metastasis was analyzed.Results：The number of CD8＋T cell was significantly increased in colorectal cancer with regional draining lymph nodes metastasis than those without lymph node metastasis,and the number of CD4＋T cell,CD4＋/CD8＋level was positively decreased.Conclusions：Immune dysfunction is existence in colorectal regional draining lymph nodes,and it may be related with colorectal cancer invasion and metastasis.

关 键 词：结直肠恶性肿瘤 T淋巴细胞亚群 免疫组化 

分 类 号：R735.34[医药卫生—肿瘤]