总胆固醇水平对首发青年抑郁症患者认知功能的影响研究  

Effects of total cholesterol level on the cognitive function in first-episode depression in young patients

作　　者：周珊珊[1] 李宁[2] 刘维娟[1] 何津春[1] 张永霞 

机构地区：[1]兰州大学第一医院检验科,甘肃兰州730000 [2]兰州大学第二医院精神卫生科,甘肃兰州730000 [3]甘肃省玉门市医院检验科,735200

出　　处：《国际检验医学杂志》2013年第14期1828-1829,1832,共3页International Journal of Laboratory Medicine

基　　金：国家"十五"重大科技专项(2002DA711A028-17);教育部科技基础平台建设(505015)

摘　　要：目的探究正常血清总胆固醇(TC)范围内总胆固醇水平对首发青年抑郁症患者认知功能的影响。方法将128例抑郁症患者分为研究组(3.1<TC<4.3mmol/L)和对照组(4.3≤TC<5.5mmol/L),然后对两组进行认知功能的对照性评估,用韦氏成人智能量表、韦氏记忆量表、威斯康星卡片分类测验评估其认知功能。结果研究组的数字广度、图画填空、再认、长时记忆[分别为(9.74±2.40)分、(5.54±1.65)分、(8.07±2.35)分、(35.28±6.87)分]与对照组[分别为(10.74±2.91)分、(6.30±1.91)分、(8.98±2.76)分、(51.32±13.41)分],差异有统计学意义(P<0.05);研究组的理解和持续错误数[分别为(6.41±2.57)分,(69.02±11.42)分]与对照组[分别为(8.28±2.23)分、(54.11±12.92)分]差异有极显著性(P<0.01)。结论血清总胆固醇偏低组的认知水平较偏高组差,低胆固醇水平在抑郁症自杀方面扮演一定角色,低认知水平对评估抑郁症自杀风险有重要意义。Objective To study the effect of cholesterol levels within the normal range of serum cholesterol on cognitive function in patients with first-episode depression in youth.Methods 128 depression patients were divided into the study group and control group.The cognitive function were measured by WAIS-RC,Wechsler Memory Scale and Wisconsin Card Sorting Test（WCST）.Results There were significant differences in some neuropsychological tests between experimental and control groups（P0.05）,such as digit span（9.74±2.40,10.74±2.91）,pictures fill in the blank（5.54±1.65,6.30±1.91）,visual recognition（8.07±2.35,8.98±2.76）,and long term memory（35.28±6.87,51.32±13.41）.For understanding（6.41±2.57,8.28±2.23）and persistent number of errors（69.02±11.42,54.11±12.92）,there was significant difference between the two groups（P0.01）.Conclusion The cognitive level of the group of low serum total cholesterol is poor than that of the group of high serum total cholesterol.Low cholesterol level plays a certain role in depression suicide.Low level of cognition is important to assess depression suicide risk.

关 键 词：抑郁症 胆固醇 神经心理学测验 记忆 

分 类 号：R749.4[医药卫生—神经病学与精神病学]