炎症在帕金森病中的作用  

Inflammation in Parkinson's Disease (review)

作　　者：袁廷伟[1,2] 孙芳玲[1] 蒋莹[1] 艾厚喜[1] 张丽[1] 王文[1] 龚大春[2] 

机构地区：[1]首都医科大学宣武医院药物研究室,北京市100053 [2]三峡大学,湖北宜昌市443002

出　　处：《中国康复理论与实践》2013年第7期640-644,共5页Chinese Journal of Rehabilitation Theory and Practice

基　　金：科技部"十二五"重大创新药专项(No.2012ZX09102-201-016);国家自然科学基金(No.81173575);国家自然科学基金(No.30740053);北京市自然科学基金(No.7062031);北京市教委科研基地-科技创新平台(No.111219);北京市卫生系统高层次卫生技术人才(No.2011-3-097)

摘　　要：帕金森病是中老年人常见的神经变性疾病,以黑质致密部多巴胺能神经元进行性缺失、纹状体多巴胺水平降低为主要特点。中枢神经系统炎症和全身炎症都会导致多巴胺能神经元变性和死亡;抑制中枢神经炎症,靶向调节全身炎症、减轻外周损伤对大脑的影响,有助于缓解和阻止病情的发展,给帕金森病的预防和治疗提供新思路。Parkinson’s disease is a common progressive neurodegenerative disorder among old people,characterized by progressive loss of dopamine-producing neurons in the substantia nigra pars compacta and accordingly low level of dopamine in the nigrostriatal pathway.Neuroinflammation and even systemic inflammation have been suggested to be involved in the demise of dopaminergic neurons.Anti-inflammatory treatment could protect brain from inflammatory injury and prevent the progressive course of Parkinson’s disease,which suggests a potential new strategy for Parkinson’s disease treatment.

关 键 词：帕金森病 神经炎症 全身炎症 综述 

分 类 号：R742.5[医药卫生—神经病学与精神病学]