Lkb1维持造血干细胞稳态及其机制研究进展  

Lkb1 regulates the homeostasis of hematopoietic stem cell and the progress of its mechanism research

作　　者：李程程[1] 孟爱民[1] 

机构地区：[1]中国医学科学院放射医学研究所天津市核医学重点实验室,天津300192

出　　处：《生命科学》2013年第7期654-660,共7页Chinese Bulletin of Life Sciences

基　　金：国家自然科学基金海外合作基金项目(81129020);国家自然科学基金面上项目(81072237);天津市重点基金项目(11JCZDJC19100);国家重点基础研究发展计划(“973”项目)重大专项(2011CB964800-G)

摘　　要：造血干细胞(haematopoietic stem cells,HSCs)具有自我更新功能,可分化成多系血细胞。微环境、活性氧(reactive oxidative species,ROS)、细胞周期调控分子和能量代谢等对HSCs的稳态具有调节作用。抑癌基因Lkb1,又名STK11(serine threonine protein kinase 11),在多种细胞内磷酸化激活蛋白激酶AMPK(AMP-activated protein kinase),调节机体代谢和细胞增殖。近期研究发现,Lkb1在HSCs的代谢调控及稳态维持中发挥重要作用。对Lkb1在HSCs数量、功能、代谢的稳态维持中的作用研究进展进行综述。Haematopoietic stem cells （HSCs） has the potentiality to renew themselves and to differentiate into specialized blood cells. The niche, ROS, cell cycle regulatory factor, and energy metabolism do influence the homeostasis of HSCs. Lkbl promotes the phosphorylation of AMPK, regulating the organism metabolism and cell growth. The recent research discovered that Lkbl has important role in the regulation of metabolism and maintaining homeostasis of HSCs. This article reviewed the research progress about the role of Lkbl in the quantity, function, and metabolism homeostasis of HSCs.

关 键 词：造血干细胞 LKB1 稳态 腺苷酸活化蛋白激酶 

分 类 号：Q812[生物学—生物工程] R730.2[医药卫生—肿瘤]