血管内皮生长因子对非小细胞肺癌术后生存率的影响  

Effects of vascular endothelial growth factor on survival rate in resected non small cell lung cancer

作　　者：王慧敏[1] 廖美琳[1] 冯久贤[1] 江晓丰[1] 陈岗[1] 朱大为[1] 

机构地区：[1]上海市胸科医院肺科,上海200030

出　　处：《中国癌症杂志》2000年第4期299-302,共4页China Oncology

基　　金：上海市卫生局青年科研基金! ( 994Y15 )

摘　　要：研究血管内皮生长因子 (VEGF)在非小细胞肺癌 (NSCLC)组织中的表达与预后。方法 :用免疫组化技术测定 12 7例NSCLC的VEGF表达 ,并以Kaplan Meier曲线描述生存率 ,Cox单、多因素分析VEGF表达与生存率的关系。结果 :12 7例根治切除的非小细胞肺癌中 ,VEGF高表达者 5 2例 ,低表达者 75例 ,占 40 9%。经统计分析 ,VEGF表达与年龄、性别、病理类型、期别均无关 ;VEGF高表达者预后较低表达患者差 ,尤其在Ⅰ期和女性病人中 ,五年生存率分别为 6 1 3%和 81 1%及 40 2 %和 73 1% ,但无统计学意义 (P >0 0 5 )。结论 :VEGF对判断NSCLC预后有一定的参考价值 。Purpose:To study the expression of vascular endothelial growth factor (VEGF) and its prognostic value in non small cell lung cancer (NSCLC) Methods:VEGF expression was determined in 127 patients with NSCLC by an immunohistochemical technique. Survival curves were plotted according to the Kaplan Meier estimates. A uivariate and a multivariate analysis with Cox's model were performed to clarify the association between VEGF and survival rate. Results:Of 127 patients with radically resected NSCLC, the high and low expression of VEGF were 52 and 75 patients, respectively. The high expression ratio of VEGF was 40.9%. By statistical analysis, the VEGF expression was not related to age, sex, tumor type and stage. The prognosis of patients with high VEGF expression was worse than that of the patients with low VEGF expression,especially in stage Ⅰ or female patients. 5 year survival rate of high and low VEGF expression were 61.3% and 81.1% in stage Ⅰ, 40.2% and 73.1% in female patients. But there was no statistical significance (P>0.05). Conclusions:VEGF has a reference value for the judgement of prognosis in the NSCLC. It is worthwhile to make an intensive multicenter study to see whether VEGF could be an independent prognostic indicator.

关 键 词：非小细胞肺癌 血管内皮生长因子 预后 手术后 

分 类 号：R734.2[医药卫生—肿瘤]