中晚期非小细胞肺癌化疗和放疗综合治疗进展  

Advances in treatment of combined modality for locally advanced non small cell lung cancer

作　　者：陈桂园[1] 王丽娟[1] 蒋国梁[1] 

机构地区：[1]复旦大学医学院附属肿瘤医院放疗科,上海200032

出　　处：《中国癌症杂志》2000年第4期357-359,共3页China Oncology

摘　　要：肺癌确诊时大部分已属中晚期 ,不宜手术治疗 ,只宜非手术治疗。肺癌的治疗效果近数十年来没有显著提高 ,总的治愈率约 1 0 %。化疗和放疗的综合治疗有可能提高局控率和生存率。其综合应用有 3种方式 :序贯、同期、交替治疗。本文综述了近年来中晚期非小细胞肺癌的化疗和放疗综合应用的理论基础与临床研究 ;The majority of patients present with locally advanced disease when diagnosed as non small cell lung cancer(NSCLC) and are not suitable for surgical resection. Progress has been slow, however, the overall survival of all patients about 10% has remained essentially unchanged for the past 20 years. Combined modality therapy of locally advanced NSCLC has become a widely used means of treatment with several reports of benefit found in clinical trials. These two modalities(ie,radiotherapy and chemotherapy) have been given sequentially,concurrently,and in an alternating fashion with varying degrees of success. This paper reviews the possible mechanisms for combining radiation and chemotherapy,the status of recent and current clinical trials,and outlines some directions for future research.

关 键 词：非小细胞肺癌 放射治疗 综合治疗 药物疗法 

分 类 号：R734.205[医药卫生—肿瘤]