IL-10-1082基因多态性与中国人胃癌遗传易感性关系的荟萃分析  

A Meta-analysis on Association between Polymorphism of IL-10-1082 and Chinese Gastric Cancer

作　　者：李丹妮[1] 张佳骥[1] 马建忠[2] 

机构地区：[1]中国医科大学第94期七年制,沈阳110001 [2]中国医科大学基础医学院数学教研室,沈阳110001

出　　处：《中国医科大学学报》2013年第7期604-607,611,共5页Journal of China Medical University

基　　金：国家自然科学基金(60574040)

摘　　要：目的系统评价白细胞介素10-1082(IL-10-1082)基因多态性与中国人群胃癌遗传易感性之间的关联性。方法检索Pubmed数据库、EMBASE数据库、万方数据库、CNKI数据库等发表的有关IL-10-1082基因多态性与胃癌发病风险的文献,应用Review Manager 4.2软件进行分析,得到合并的优势比(OR)和95%可信区间(95%CI)。结果共纳入IL-10-1082 A/G多态性相关文献15篇,累计病例2 327例,对照3 447例,并得到IL-10基因的多态位点1082等位基因G的OR值(95%CI)为1.66(1.33～2.07)。结论 IL-10-1082 G/A遗传位点与中国人群胃癌发病危险存在关联性。Objective To explore the association between IL-10-1082 polymorphism and gastric cancer in Chinese population. Methods The ease-control studies on both IL-10-1082 polymorphism and GC risk were searched through Pubmed,EMBASE,Wanfang,and CNK1 et al, and data from identified studies was collected. Review Manager 4.2 was applied for the calculation of pooled OR（95%CI）of GC. Results Totally 15 ease-control studies were identified in the analysis, including 2327 GC eases arid 3447 controls. The pooled odds ratios（95%Cl ）of 1L-10-1082 is 1.66（ 1.33-2.07 ）. Conclusion IL-10-1082 G/A SNP is associated with GC risk in Chinese population.

关 键 词：胃癌 SNP IL-10—1082 中国人 META分析 

分 类 号：R735.2[医药卫生—肿瘤]