尼莫地平脉冲控释微丸的制备  

Preparation of nimodipine pulsaltile controlled-release pellets

作　　者：李菲[1] 郝吉福[1] 郭丰广[1] 王建筑[1] 毕研平[1] 李芊葵[1] 

机构地区：[1]泰山医学院药学院,泰安271016

出　　处：《中国新药杂志》2013年第15期1828-1830,共3页Chinese Journal of New Drugs

基　　金：泰山医学院青年基金(2009ZRQN064)

摘　　要：目的:制备尼莫地平脉冲控释微丸,考察影响体外脉冲释药的因素。方法:以低取代羟丙基纤维素为膨胀剂,采用挤出-滚圆法制备丸芯,以乙基纤维素为包衣材料,肠溶性聚丙烯酸树脂为致孔剂,采用流化床包衣法制备尼莫地平脉冲控释微丸,考察膨胀剂用量、致孔剂用量和包衣增重对微丸释药行为的影响。结果:当膨胀剂比例为30%,包衣液EC∶EudragitL30D-55=4∶25,包衣增重15%时,微丸释药时滞为4.0 h。结论:通过对膨胀剂用量、包衣液中致孔剂用量和包衣增重进行筛选可以得到具有适当释药时滞和释药速度的脉冲控释微丸。Objective：To prepare nimodipine pulsahile controlled-release pellets and investigate the drug release characteristic in vitro. Methods：Core pellets using L-HPC as swelling agent were prepared using extrusion- spheronization method. The resultant core pellets were coated using fluidized bed coating technology with EC as coating material and Eudragit as pore forming agent. The effects of swelling agent,pore forming agent and the coat- ing thickness on drug release of the pellets were investigated. Results：The in vitro lag time of drug release was 4.0 h when the amount of disintegrant was 30% ,the ration of EC to EudragitL30D-55 was 4：25 ,and the thickness （weight） of the coating film was 15%. Conclusion：Nimodipine pulsaltile release pellets with proper lag time and drug release rate can be obtained by screening the amounts of swelling agent and pore forming agent as well as the coating thickness.

关 键 词：尼莫地平 脉冲控释微丸 包衣 时滞 

分 类 号：R943.41[医药卫生—药剂学] R972.4[医药卫生—药学]