手性M受体拮抗剂N-烯丙基苯环壬酯的合成  

Synthesis of chiral M receptor antagonist N-ally phencyclonate

作　　者：刘河[1] 陈慧[1] 刘丽宏[1] 

机构地区：[1]首都医科大学附属北京朝阳医院,北京100020

出　　处：《化学试剂》2013年第8期753-755,共3页Chemical Reagents

基　　金：国家自然科学基金资助项目(81072530)

摘　　要：利用手性拆分的方法,通过光学纯的N-对甲苯磺酰基谷氨酸拆分2'-苯基-2'-环戊基-2'-羟基乙酸-9α-[3-氮杂双环(3.3.1)壬]酯得到光学异构体,然后与烯丙基溴反应合成得标题化合物。（ R ）-9α-[ N-Methyl-3-azabicyclo （ 3. 3. 1 ） nona-nyl ]-α-cyclopentyl-α-hydroxy-α-phenylacetate hydrochloride （R-I） was synthesized by transesterification of （R）-methyl α-cyclopentyl-α-hydroxy-α-phenylacetate with N-methyl-3-az-abicyclo（3.3. 1 ）nonane-9α-ol. The structure was confirmed by infrared spectrum, the nuclearmagnetic resonance （ HN-MR） ,CNMR,H-C COSY and DEPT. The chemical shifts of ^1HNMR and ^13CNMR were assigned by means of ^1H-^1C-CO-SY and DEPT. The vibrations of functional group of this com-pound were discussed.

关 键 词：手性药物 M受体拮抗剂 手性拆分 

分 类 号：R914.5[医药卫生—药物化学]