脑组织移植治疗持续性植物状态  

Treatment of persistent vegetative state by brain tissue transplantation

作　　者：王溶杨[1] 向月应[1] 郑宝轩[1] 汪亚东[1] 吴佐泉[2] 徐智琼[1] 龙兰英 

机构地区：[1]解放军第181医院,桂林541002 [2]解放军广州军区武汉总医院

出　　处：《中华器官移植杂志》2000年第6期369-371,共3页Chinese Journal of Organ Transplantation

基　　金：广西自然科学基金资助项目(9732034)

摘　　要：目的　总结脑组织移植治疗持续性植物状态 (PVS)的疗效 ,探讨其机制。方法　制定PVS病情量表和疗效判定标准 ,采用胎脑组织移植治疗PVS 2 3例 ,术后 2个月评定疗效。结果　 2 3例中有效 5例 (2 1.7% ) ,显效 13例 (5 6 .5 % ) ,总有效率 78.3 %。结论　脑组织移植是治疗PVS的一种有效方法。移植术后早期患者意识和功能的改善与移植物为患者提供了大量外源性神经营养因子和神经递质有关。Objective To summarize the therapeutic effects of fetal brain tissue transplantation in the treatment of persistent vegetative state (PVS), and to investigate its mechanisms. Methods The grade table of PVS and the standard of scoring the therapeutic effects were drawn up. Twenty three patients were treated by fetal brain tissue transplantation. The therapeutic effects were scored 2 months after transplantation. Results Five patients ( 21.7 ?%) out of the 23 patients were scored effectiveness and 13 ( 56.5 ?%) obvious effectiveness. Total effective rate was 78.3 ?%. Conclusions The fetal brain tissue transplantation is a effective method for treating PVS. Improvements of the consciousness and function of patients in early period after transplantation is referred to be concerned with the grafts offering massive exterior neurotrophic factors and neurotransmitters.

关 键 词：脑 组织移植 持续性植物状态 

分 类 号：R742.05[医药卫生—神经病学与精神病学] R651[医药卫生—临床医学]