血清CEA检测在消化道恶性肿瘤诊断中的临床价值  

Clinical Value of Serum CEA Detection in the Diagnosis of Malignant Tumor in the Digestive Tract

作　　者：李凤焕 王晓东 向鑫 

机构地区：[1]解放军第二五四医院检验科,天津300142

出　　处：《中国医药导刊》2013年第6期1049-1049,1051,共2页Chinese Journal of Medicinal Guide

摘　　要：目的:探讨肿瘤标志物癌胚抗原(CEA)检测在消化道恶性肿瘤诊断中的价值。方法:选择2009年8月～2012年2月我院住院和门诊的144例消化道恶性肿瘤患者作为观察组,其中胰腺癌32例,肝癌29例,结直肠癌38例,胃癌45例,并选择50例健康体检者作为对照组,用ELISA法检测其血清中CEA的水平。对CEA在不同种类的消化道恶性肿瘤中的阳性率进行分析。结果:CEA在结直肠癌患者组的阳性率最高,为60.53%(23/38)、胰腺癌为46.88%(15/32)、肝癌和胃癌分别为34.48%(10/29)和33.33%(15/45)。结论:在不同类型的消化道恶性肿瘤中,CEA的表达有一定的差异性,在结直肠癌中的表达率最高,胰腺癌次之、再次是肝癌和胃癌。各肿瘤组与健康对照组间比较均存在显著性差异(P<0.01)。Objective：To investigate the tumor markers carcinoembryonic antigen（CEA） detection of clinical volue in the diagnosis of gastrointestinal malignant tumors.Methods：To choose 144 cases of patients with gastrointestinal tumors during 2009.8～2012.2 as the observation groups,including 32 cases of pancreatic cancer,29 cases of liver cancer,38 cases of colorectal cancer,and 45 cases of gastric cancer.50 cases of healthy persons as the control group,the content of serum CEA were measured by using ELISA.The positive rate of CEA in different types of gastrointestinal tumors were analyzed.Results：CEA positive rate in the group of patients with colorectal cancer was 60.53%（23/38）,pancreatic cancer was 46.88%（15/32）,liver cancer and gastric cancer was 34.48%（10/29） and 33.33%（15/45） respectively,Conclusion：Among the above-mentioned different types of gastrointestinal malignant tumors,CEA expressed in certain differences,the positive expression of the highest rates of CEA was in colorectal cancer,then followed by pancreatic cancer,liver cancer and stomach cancer.There existed a significant statistical difference between the observation groups and control group（P〈0.01）.

关 键 词：肿瘤标志物 CEA 消化道恶性肿瘤 临床价值 

分 类 号：R735[医药卫生—肿瘤]