内质网、线粒体与脑缺血再灌注  

Endoplasmic reticulum, mitochondria and cerebral ischemia-reperfusion injury

作　　者：卢俊江[1] 李明亮[1] 韩江全[1] 

机构地区：[1]遵义医学院第五附属(珠海)医院神经内科,广东珠海519100

出　　处：《中国现代医生》2013年第23期20-22,共3页China Modern Doctor

基　　金：贵州省科技厅科研课题(黔科合J字[2010]2174号);广东省珠海市医学重点学科项目资助(珠卫200880)

摘　　要：内质网和线粒体是细胞内合成、分泌、加工和运输蛋白质等物质以及维持机体能量代谢稳定的重要场所,然而在面临创伤、缺血、缺氧等环境因子超负荷作用时,又通过复杂的病理生理过程最终导致细胞凋亡,甚至死亡。脑卒中是临床上的常见病,脑缺血再灌注损伤是影响卒中患者治疗效果的首要因素之一,是医务工作者及患者所共同面临的棘手问题。目前,线粒体和内质网应激途径在诱导细胞凋亡及抗细胞凋亡研究中的地位日趋明显,内质网应激与线粒体通路及其在脑缺血再灌注损伤中的研究具有重要意义。Endoplasmic reticulum and mitochondria are the crucial places for synthesis, secretion, processing, protein transport and energy metabolism maintenance in the cells. However, during the processes of trauma, ischemia, hypoxia and other environmental factors while overload, they will eventually lead to apoptosis or even death via complex patho- physiological process. Stroke is a common clinical disease, and cerebral ischemia-reperfusion injury is not only one of the primary factors affecting the patients with stroke, but also a thorny issues which the medical workers and patients are facing together. At present, the importance of study about apoptosis induction and anti-apoptotic on endoplasmic reticulum stress and mitochondrial pathways has become increasingly evident. The research progress of the endoplas- mic reticulum stress and mitochondrial pathways and their synergy effect in cerebral ischemia reperfusion injury is summarized as follows.

关 键 词：内质网 应激 线粒体 通路 脑缺血再灌注损伤 

分 类 号：R743.3[医药卫生—神经病学与精神病学]