盐酸法舒地尔对急性脑梗死的临床治疗效果和安全性分析  

The Effectivity and Safety of Fasudil Hydrochloride Used in Treatment of Acute Cerebral Infarction (ACI)

作　　者：林青[1] 宋伟峰[2] 

机构地区：[1]中山大学附属第一医院黄埔院区,广东广州510700 [2]中山大学附属第三医院,广东广州510630

出　　处：《中国医药指南》2013年第21期431-432,共2页Guide of China Medicine

摘　　要：目的探讨盐酸法舒地尔治疗急性脑梗死的有效性和安全性。方法 110例急性脑梗死患者被随机分为观察组和对照组,两组均给予综合治疗,观察组加用盐酸法舒地尔治疗。结果①治疗后两组IL-1、IL-6、hs-CRP和TNF-α均有显著性改善(均P<0.01),但观察组改善程度显著大于对照组(均P<0.01)。②观察组总有效率大于对照组,但无显著性差异(P<0.05);显效率显著大于对照组(P>0.05);副反应率大于对照组,但无显著性差异(P>0.05)。两组均未出现严重副反应。结论盐酸法舒地尔辅助治疗急性脑梗死,有效性和安全性高,值得临床考虑。Objective To explore the effectivity and safety of fasudil hydrochloride used in treatment of ACI. Methods 85 cases of patients with ACI were randomly divided into experimental group and control group. Both groups were given comprehensive treatment, and experimental group were added to therapy of fasudil hydrochloride. Results （1）After therapy, IL-1, IL-6, hs-CRP and TNF-α in two groups significantly improved for well（all P〈0.01）, but improving degree in experimental group was significantly better than in control group（all P〈0.01）. （2）Compared with control group, the total effective rate in experimental group was higher, but no significant difference （P〉0.05）; the efficiency rate was significantly higher （P〈0.05）; the side-reaction rate was higher, but no significant difference, too （P〉0.05）. There was no serious side-reaction happened. Conclusion Adjuvant therapy of fasudil hydrochloride used for ACI, show high effectivity and safety, so it deserved considering in clinical work.

关 键 词：盐酸法舒地尔 急性脑梗死 有效性 安全性 

分 类 号：R743.3[医药卫生—神经病学与精神病学]