重组组织型纤溶酶原激活剂动静脉联合溶栓和静脉溶栓治疗急性后循环缺血性脑卒中疗效比较  

Comparision of the efficacy of the combined intravenous and intra-arterial with intravenous thrombolytic treatment of acute posterior circulation stroke with rt-PA

作　　者：胡亮[1] 李欣[1] 李雯[1] 

机构地区：[1]上海市杨浦区中心医院神经内科,上海200090

出　　处：《吉林医学》2013年第22期4424-4426,共3页Jilin Medical Journal

摘　　要：目的:比较重组组织型纤溶酶原激活剂(rt-PA)动静脉联合溶栓和静脉溶栓治疗急性后循环缺血性脑卒中的有效性和安全性。方法:回顾急性后循环缺血性卒中患者18例,其中静脉溶栓14例,动静脉联合溶栓4例;比较两组患者治疗前及治疗后2小时、24小时、3天、7天、21天(出院时)美国国立卫生院卒中量表(NIHSS)。结果:两组患者治疗后2小时、3天、7天、21天(出院时)的NIHSS评分和治疗前相比有明显差异(P<0.05),两组之间评分无明显差异(P>0.05)。结论:重组组织型纤溶酶原激活剂动静脉联合溶栓和静脉溶栓治疗急性后循环缺血性卒中均有效和安全。Objective To compare the efficacy and safety of the combined intravenous and intra-arterial with intravenous thrombolytic treatment of acute posterior circulation stroke with rt-PA.Method We analyzed 18 patients diagnosed as acute posterior circulation stroke retrospectively,4 of which were treated by combined intravenous and intra-arterial thrombolytic with rt-PA while the other 14 by intravenous thrombolytic.Compared the safety and the outcome assessment judging by National Institutes of Health Stroke Scale（NIHSS） before and 2 h,1 d,3 d,7 d,21 d after thrombolysis.Results 2 h,3 d,7 d,21 d after treatment,the NIHSS in patients with combined ntravenous and intra-arterial or intravenous thrombolytic were also much lower than before thrombolysis.There was no significant difference between these two groups.Conclusion Combined intravenous and intra-arterial or intravenous thrombolytic treatment of acute posterior circulation stroke with rt-PA are both effective and safe.

关 键 词：重组组织型纤溶酶原激活剂 动静脉联合溶栓 后循环缺血性卒中 

分 类 号：R743.3[医药卫生—神经病学与精神病学]