奥拉西坦对脑白质疏松老年患者认知功能改善的临床观察  

Efficacy of oxiracetam therapy of elderly patients with cognitive impairment and leukoaraiosis

作　　者：李蔚渤[1] 屈引贤[1] 

机构地区：[1]西安市中心医院老干科,陕西西安710003

出　　处：《西部医学》2013年第8期1206-1207,共2页Medical Journal of West China

摘　　要：目的观察奥拉西坦对老年脑白质疏松伴认知功能障碍患者的疗效。方法将60例老年脑白质疏松伴认知功能障碍的患者随机分成治疗组和对照组各30例,两组均给予常规治疗,治疗组加奥拉西坦胶囊800mg,3次/日,治疗前及治疗后24周进行简易智力状态量表(MMSE)及蒙特利尔量表(MoCA)评定认知状况。结果治疗24周后,治疗组MMSE及MoCA评分高于对照组,差异有显著性(P<0.01);与治疗前比较,治疗组治疗后MMSE及MoCA评分增加,差异有统计学意义(P<0.01),而对照组治疗前后MMSE及MoCA评分差异无统计学意义(P>0.05)。结论奥拉西坦能改善脑白质疏松老年患者的认知功能。Objective To explore the clinica） effects of Oxlracetam in treament the elderly patients with cognitive impairment and leukoaraiosis. Methods 60 elderly patients were divided into two groups randomly according to different treatment,30 patients receiving Oxiracetam treatment （treatment group） for 24 weeks, 30 patients without （control group）. MMSE and MoCA were measured before and after treatment. Results After 24 weeks, the MMSE and MoCA scors of treatment group were significantly higher than that of control group by the statiscal analysis （P〈0. 01）. Com- pared with before treatment, the MMSE and MoCA scors of treatment group were significantly increasd after treatment （P〈0. 01）. But in control group, the difference of the MMSE and MoCA scors were no significant before and after treat- ment （P〉0.05）. Conclusion Oxiraeetam can improve the cognite of the elderly patients with leukoaraiosis.

关 键 词：奥拉西坦 脑白质疏松 认知功能障碍 

分 类 号：R743[医药卫生—神经病学与精神病学]