癌痛形成机制及模型研究进展  

Research advance on cancer pain mechanism and model

作　　者：王晶[1] 胡卫[1] 詹玲[1] 万信念[1] 焦良波[1] 陈涛[1] 

机构地区：[1]三峡大学医学院,湖北宜昌443002

出　　处：《安徽医药》2013年第8期1269-1271,共3页Anhui Medical and Pharmaceutical Journal

基　　金：国家自然科学基金项目(No 81173612)

摘　　要：癌痛是一个复杂的病理学过程,同时也是临床上的一大难题。近年来,为了给临床上癌痛的治疗提供更可靠、有效的方法,研究者通过构建适当的动物模型进行对癌痛的机制和治疗的基础研究。目前,已经成功研究出几种癌痛动物模型,包括骨癌痛模型、皮肤癌痛模型、面癌痛、神经癌痛、内脏肿瘤牵扯痛模型及化疗药物引起的化疗痛。这些模型说明癌痛不同的药理学和神经化学。该文对不同的癌痛模型做一总结,为进一步的研究提供参考。Cancer pain is a complicated process of pathology,and a severe problem clinically.Recently,basic research on the mechanisms and treatments of cancer pain would be enhanced by the development of adequate animal models to provide reliable and effective mothods.Now,several kinds of animal models of cancer pain have been developed.These include bone cancer pain,skin cancer pain,facial cancer pain,neuropathic cancer,viscera cancer referred pain and chemotherapy pain.These models have demonstrated the distinct pharmacological and neurochemical aspects of cancer pain.The paper makes a summary of different cancer pain models,in order to provide theory reference for additional research.

关 键 词：癌痛模型 行为学 机制 

分 类 号：R730.5[医药卫生—肿瘤]