伊托必利、兰索拉唑联合氟哌噻吨美利曲辛及心理干预治疗功能性消化不良  

Effects of Combined Treatment with Itopride,Lansoprazole and Flupentixol Melitracen and Psychological Intervention on Functional Dyspepsia

作　　者：黄更珍[1] 贺国斌[1] 张耀丹[2] 廖娟[1] 陈予[1] 明文[1] 左锦[1] 张琴[1] 

机构地区：[1]川北医学院附属医院消化内科,四川南充637000 [2]川北医学院附属医院神经内科,四川南充637000

出　　处：《南昌大学学报（医学版）》2013年第5期33-35,39,共4页Journal of Nanchang University：Medical Sciences

摘　　要：目的探讨伊托必利、兰索拉唑联合氟哌噻吨美利曲辛及心理干预治疗功能性消化不良(functional dys-pepsia,FD)的疗效。方法将120例FD患者按随机数字表法分为2组,每组60例。治疗组:伊托必利50mg,3次.d-1,饭前服;兰索拉唑30mg.次-1,1次.d-1,早晨空腹顿服;氟哌噻吨美利曲辛10.5mg,1次.d-1,中午饭前服;同时对所有患者进行心理干预。对照组:伊托必利50mg,3次.d-1,饭前服;兰索拉唑30mg.次-1;1次.d-1,早晨空腹顿服。2组疗程均为8周。比较2组患者的临床疗效及抑郁自测量表(SDS)和焦虑自测量表(SAS)表评分,并比较治疗期间2组患者不良反应率的差异。结果治疗8周后,治疗组总有效率为96.67%,明显高于对照组(85.00%)(P<0.05);治疗组不良反应发生率为8.33%,明显低于对照组(14.99%)(P<0.05);治疗后伴抑郁、焦虑患者治疗组明显少于对照组(P<0.05)。结论应用伊托必利、兰索拉唑联合氟哌噻吨美利曲辛及心理干预治疗功能性消化不良疗效确切,不良反应小。Objective To investigate the effects of combined treatment with itopride,lansoprazole and flupentixol melitracen and psychological intervention on functional dyspepsia（FD）.Methods A total of 120 patients with FD were randomly treated with itopride 50 mg three times daily before meals and lansoprazole 30 mg once daily on an empty stomach（control group,n=60） or in combination with flupentixol melitracen 10.5 mg once daily before lunch（treatment group,n=60） for 8 weeks.In addition,all patients were given psychological intervention.Clinical efficacy,SDS scores,SAS scores and adverse reactions were compared between the two groups.Results Compared with control group,the total effective rate significantly increased and incidence of adverse reactions obviously decreased in treatment group（96.67% vs 85.00% and 8.33% vs 14.99%,respectively;P〈0.05）.Furthermore,the incidence of depression and anxiety in treatment group was markedly lower than that in control group（P〈0.05）.Conclusion Combined treatment with itopride,lansoprazole and flupentixol melitracen and psychological intervention are effective and produce less adverse reactions in patients with FD.

关 键 词：功能性消化不良 伊托必利 兰索拉唑 氟哌噻吨美利曲辛 心理干预 

分 类 号：R574.4[医药卫生—消化系统]