老年人抑郁障碍与认知功能水平损害的关系  

Relationship of depressive disorders and cognitive function impairment for the elderly

作　　者：杨振东[1] 陈定华[1] 瞿正万[1] 江琦[1] 张明[1] 孙喜蓉[1] 朱莉娜[1] 傅伟忠[1] 袁杰[1] 裴瑜[1] 傅红梅[1] 秦虹云[1] 

机构地区：[1]上海市浦东新区精神卫生中心,上海200124

出　　处：《中国民康医学》2013年第15期104-107,共4页Medical Journal of Chinese People’s Health

基　　金：上海市浦东新区政府基金资助项目(PKJ2010-y26)

摘　　要：目的:探讨老年人群抑郁障碍对认知功能活动的可能影响及其相互关系。方法:抽样调查了上海市浦东新区24个村(居)委55岁以上居民3 903例,进行蒙特利尔认知评估(MoCA),应用美国精神障碍诊断与统计手册第4版(DSM-IV-TR)轴I障碍定式临床检查法调查和诊断。结果:老年抑郁障碍患者共519人,恶劣心境最多(54.91%),重性抑郁最少(5.4%)。各类老年抑郁障碍组与阴性组比较,其MoCA总分、记忆力、注意力、流畅性、抽象能力及延迟回忆等因子均分存在显著差异(P<0.05),Logistic回归分析显示,抑郁阳性与性别、职业、生活能力、糖尿病、高脂血症等易感因素相关(P<0.05)。结论:老年抑郁障碍者的认知功能损害涉及面较广,与抑郁严重度成正比,积极治疗抑郁障碍能有效改善认知功能水平。Objective： To explore possible effects of depressive disorder on cognitive function for the elderly,and investigate relationship of them.Methods： Montreal cognitive assessment（MoCA） and simplified version of the SCID depression disorders questionnaire were administered to 3903 participants from 24 villages（neighborhood） committees in Pudong new area.Results： There were 519 cases with depressive disorder,wherein the most cases suffered from dysthymia（54.91%） and the least cases had major depression（5.4%）.There were significant differences in factor scores like MoCA total score,memory,attention,verbal fluency,abstract ability,and delayed recall between elderly depressive disorder group and negative group（P ＆lt; 0.05）.Logistic regression analysis showed that gender,occupation,life ability,diabetes and hyperlipoidemia were risk factors for elderly depressive disorder.Conclusions： The cognitive function impairment of the elderly with depressive disorder is broad and is positively correlated with the depsression severity.An active treatment can effectively improve the cognitive fuction levels.

关 键 词：抑郁障碍 老年人 MOCA 认知功能 

分 类 号：R749.41[医药卫生—神经病学与精神病学]