帕瑞昔布钠用于直肠癌手术超前镇痛效果观察  

Preemptive Analgesia Efficacy of Parecoxib Sodium Used in Surgery for Rectal Carcinoma

作　　者：张乙[1] 姜万维[1] 崔金花[1] 王庆辉[1] 崔进[1] 隋成[1] 周晶[1] 于学美[1] 

机构地区：[1]大连大学附属新华医院麻醉科,辽宁大连116021

出　　处：《中国肛肠病杂志》2013年第7期48-49,共2页Chinese Journal of Coloproctology

摘　　要：为观察帕瑞昔布钠对直肠癌术后的镇痛效果，将120例ASAⅠ～Ⅱ级择期行直肠癌手术患者随机分为3组，每组40例，A组于手术开始前20min静脉注射帕瑞昔布钠40mg．B组于缝皮时静脉注射帕瑞昔布钠40mg，C组（对照组）不注射帕瑞昔布钠。3组患者术后均采用1．2％氯普鲁卡因加0．01Yoo吗啡进行患者自控硬膜外镇痛（PCEA）。观察术后24h患者PCEA的总按压次数、有效按压次数、硬膜外吗啡及氯普鲁卡因用量及镇痛的补救用药率。结果显示，与C组比较，A组和B组术后24hPCEA总按压次数、有效按压次数、硬膜外吗啡及氯普鲁卡因用量和补救用药率降低（P〈O．05）；与B组比较，A组术后24hPCEA总按压次数、有效按压次数、硬膜外吗啡及氯普鲁卡因用量和补救用药使用率降低（P〈0．05）。结果表明，直肠癌手术应用帕瑞昔布钠有超前镇痛作用，能减少术后患者PCEA的按压次数，减少阿片类药物应用，提高镇痛质量。This study was to observe the analgesia efficacy of parecoxib sodium used in operation for rectal carcinoma. The 120 ASA Ⅰ～Ⅱgrade patients to be received scheduled surgery for their carcinoma were randomly divided into 3 groups,40 cases for each,group A,B,C; group A was intravenously injected with parecoxib sodium 40 mg at 20 min before operation, group B with parecoxib sodium 40 mg at suture of skin,group C （as control）,no injectied parecoxib sodium;after operation patients of the three groups all a- dopted 1.2% chloroprocaine and 0.01% morphine to perform PCEA （patients controlled epidural analgesi- a） ;Then,at 24h after operation the total press times and effective ones,the dosage of morphine and chloro- procaine and their supplement rate for analgesia in three groups were all observed. As results, compared with group C,in above 4 items group A and B were statistically reduced（ P 〈0.05） ;compared with group B in the 4 items group A reduced（ P 〈0.05）. Results show that parecoxib sodium has preemptive analgesia action,can reduce press times of PCEA, decrease dosage of opiate analgesics, thus improve the analgesia quality.

关 键 词：直肠癌 帕瑞昔布纳 镇痛 

分 类 号：R735.37[医药卫生—肿瘤]