盐酸氟桂利嗪辅助治疗癫痫临床观察  

Clinical observation of sibelium as an add-on therapy for epilepsy

作　　者：解旭东[1] 冀风云[1] 王婷[1] 

机构地区：[1]河北省保定市解放军252医院神经内科,071000

出　　处：《河北医药》2000年第8期576-577,共2页Hebei Medical Journal

摘　　要：目的　研究盐酸氟桂利嗪辅助治疗癫痫疗效。方法　 192例癫痫患者在卡马西平或丙戊酸钠治疗至少 3月后 ,添加盐酸氟桂利嗪活治疗 ,口服盐酸氟桂利嗪 5mg ,每晚 1次 ,共 3月。结果　添加盐酸氟桂利嗪治疗后 ,发作次数明显减少 (P <0 .0 1)。总有效率 47.3 % ,丙戊酸钠组有效率 5 9.8% ,卡马西平组有效率 37.1%。丙戊酸钠组明显优于卡马西平组 (P <0 .0 1)。结论　盐酸氟桂利嗪辅助治疗癫痫有效 。Objective To analyze the effect of sibelium in patients with epilepsy.Methods Sibelium was used as an add on therapy (5 mg, pernight, 3 months) in 192 patients who had been receiving carbamazepine or sodium valproate at last 3 months.Results Seizure frequency was significant decreased after adding sibelium(P< 0.01). The total effective rate was 47.3%. The effective rate was 59.8% in sodium valproate group while it was 37.1% in another. The effective rate in sodium valproate group was better (P<0.01).Conclusion Sibelium as an add on therapy for epilepsy is effective. It is better in sodium valproate group than in carbamazepine group.

关 键 词：癫痫 抗癫痫药 药物疗法 盐酸氟桂利嗪 疗效 

分 类 号：R742.105[医药卫生—神经病学与精神病学]