胃癌和非癌症患者血清各元素水平变化的临床意义  

Analysis on serum levels of trace elements among gastric cancer and non-cancer patients

作　　者：马振菁 陈发林[2] 李新民[2] 

机构地区：[1]福建省医学科学研究院福建省医学测试重点实验室,福建福州350001 [2]福建省立医院

出　　处：《中国预防医学杂志》2013年第7期503-505,共3页Chinese Preventive Medicine

基　　金：福建省自然科学基金项目(编号:2010J01134)

摘　　要：目的探讨血清的微量元素水平在健康人、胃癌,非癌症患者中变化的临床意义。方法对27例胃癌患者(胃癌组)、50例健康体检者(健康对照组)及40例非癌症但患有消化道疾病患者(非癌症对照组)采用原子吸收光谱法测定血清中各种微量元素包括铜、锌、铁、镁水平及铜/锌比值5项指标。结果健康对照组血清铜、锌、铁、镁水平分别为(0.877±0.235)mg.L-1、(2.809±0.898)mg.L-1、(13.353±4.232)mg.L-1和(21.801±2.980)mg.L-1;铜/锌比值为0.337±0.121。胃癌组与非癌症对照组比较:血清中铜水平升高明显(P<0.01),分别为(1.183±0.194)mg.L-1和(0.892±0.195)mg.L-1,铜/锌比值明显增高(P<0.01),分别为0.535±0.165和0.348±0.127,血清中铁水平明显降低,分别为(10.779±4.227)mg.L-1和(12.931±3.778)mg.L-1;胃癌组与健康对照组比较:锌水平明显降低(P<0.05)[(2.392±0.717)mg.L-1],镁水平显着升高(P<0.01)[(24.274±3.636)mg.L-1]。结论血清中铜水平升高、铜/锌比值增加及铁水平的降低是胃癌的危险因素,具有临床意义。Objective To analyze the serum levels of trace elements among patients with gastric cancer,non-cancer patients and healthy individuals,and to explore the clinical significance.Methods Serum levels of trace elements including five indicators as copper,zinc,iron,magnesium and copper/zinc ratio were detected by atomic absorption spectrometry among 27 patients with gastric cancer,50 healthy individuals and 40 non-cancer patients but suffering from other gastrointestinal diseases.Results The serum levels of copper,zinc,iron,magnesium and copper/zinc ratio were 0.877±0.235 mgoL-1,2.809±0.898 mgoL-1,13.353±4.232 mgoL-1,21.801±2.980 mgoL-1 and 0.337±0.121 among healthy individuals.Patients with gastric cancer not only had higher level of copper compared to those non cancer patients（1.183±0.194 mg·L-1 VS 0.892±0.195 mg·L-1）（P〈0.01）,but also had increased copper/zinc ratio（0.535±0.165 VS 0.348±0.127）（P〈0.01）,however,the serum level of iron was significantly lower（10.779±4.227）mg·L-1 VS 12.931±3.778 mg·L-1）.Compared to healthy individuals,patients with gastric cancer had lower level of zinc（2.392±0.717 mgoL-1）（P〈0.05）,but had higher level of magnesium（24.274±3.636 mgoL-1）（P〈0.01）.Conclusions Elevated serum level of copper coupled with increased copper/zinc ratio and low level of iron are considered to be risk factors for gastric cancer.

关 键 词：微量元素 原子吸收光谱法 胃癌 铜 锌比值 血清 

分 类 号：R735.2[医药卫生—肿瘤]