呆聪液对老龄大鼠痴呆模型脑M受体作用的实验研究  

Experimental Study of Daicong Solution on Brain M Receptor in Dementia Model of Aged Rats

作　　者：岳启安[1] 赵淑梅[1] 高敬宗[1] 李光宗[1] 阎乐法[1] 尤敏[1] 管福来[1] 

机构地区：[1]山东潍坊医学院,山东261042

出　　处：《中国中西医结合杂志》2000年第11期846-848,共3页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：山东省中医管理局基金资助课题!(No .98- 2 4 )

摘　　要：目的 :探讨呆聪液对老龄大鼠痴呆模型脑M受体的作用。方法 :选用 2 2月龄的老龄大鼠 ,采用双侧电解损毁基底核法 ,造成学习和记忆功能障碍的痴呆动物模型 ,观察了呆聪液对该动物模型脑M受体合成的影响。结果 :呆聪液的两个不同剂量试验组对老龄大鼠痴呆模型脑M受体的作用与老龄大鼠痴呆模型对照组比较差异有显著性 (P <0 0 1) ,但两个不同剂量试验组的呆聪液对老龄大鼠痴呆模型脑M受体的作用与脑复康对照组比较差异也有显著性 (P <0 0 1)。结论 :中药呆聪液具有明显提高老龄大鼠痴呆模型脑M受体数目的作用 (P <0 0 1)和提高脑M受体的亲和力 (P <0 0 1) ,改善老龄大鼠痴呆模型学习和记忆功能障碍 。Objective: To explore the effect of Daicong Solution (DCS) on M receptor in brain of aged rat model of dementia. Methods: The effects of DCS on M receptor in brain of dementia model of learning and memory function hindrance were observed, the basal nuclei were ruined by destroying bilateral electrolytic method in 22 month old rats. Results: Significant difference was shown in comparing the M receptor in the two groups treated by different dosages of DCS with that in the model control group (P<0 01), significant difference also displayed in comparison of the DCS treated groups and Naofukang treated group (P<0 01). Conclusion: DCS has marked effects in elevating the number and affinity of M receptor in brain of aged rat dementia model and could improve its learning and memory function, the effect was superior to that of Naofukang.

关 键 词：呆聪液 M受体 老年痴呆 实验研究 动物模型 

分 类 号：R749.16[医药卫生—神经病学与精神病学] R285.5[医药卫生—临床医学]