细胞穿膜肽的研究进展  

Advance on the Research of Cell-Penetrating Peptides

作　　者：孙春萌[1] 沈雁[1] 涂家生[1] 

机构地区：[1]中国药科大学药剂教研室,南京210009

出　　处：《中国药学杂志》2013年第14期1143-1147,共5页Chinese Pharmaceutical Journal

基　　金：国家科技支撑计划资助项目(2008BAI55B03);国家"重大新药创制"科技重大专项资助项目(2009ZX09310-004)

摘　　要：目的综述细胞穿膜肽的研究进展。方法以近年来研究文献为基础,对细胞穿膜肽的结构特点、分类、内化机制、应用以及新的研究方向等进行综述。结果细胞穿膜肽(cell-penetrating peptides,CPPs)是一类由不多于30个氨基酸组成的小分子多肽,根据其氨基酸组成,可分为阳离子细胞穿膜肽和两亲性细胞穿膜肽。体内外研究表明,细胞穿膜肽能够介导多种载体的穿膜作用,无刺激性,并且在一定浓度范围内对宿主细胞无毒害作用。结论细胞穿膜肽的作用机制仍需进行深入探讨,但其作为一种新型药物递送工具,具有广泛的应用前景。ObjectiveTo review the progress on cell-penetrating peptides（CPPs）. Methods Based on the original researches in recent years, the structure properties, classification, internalization mechanism, application and novel research orientation of CPPs were introduced in the present paper. Results Cell-penetrating peptides（CPPs） consisted of 30 or less amino acids. CPPs, generally categorized as amphipathic or cationic depending on their sequences, are increasingly drawing attention as a non-invasive delivery technology for macromolecules. Delivery of a diverse set of cargoes has been attempted using different types of CPPs in vitro and in vivo. Additionally, the relative lack of toxicity and cell specificity has enabled its widespread use in preclinical models. This paper reviewed the studies on the structure properties, classification, internalization mechanism, application and novel research orientation of CPPs. Conclusion Although the internalization mechanism of CPPs will be studied deeply, CPPs, as a novel drug delivery tool, has promising application for the delivery of diverse drugs and cargoes.

关 键 词：细胞穿膜肽 结构特点 分类 内化机制 

分 类 号：R944[医药卫生—药剂学]