奥氮平合用氟西汀治疗抑郁症的临床疗效观察  

The Efficacy and Safety of Olanzapine Combined with Fluoxetine in Treatment of Refractory Depression.

作　　者：张东坡[1] 张卫青[1] 施玉梅[1] 张景彦[1] 崔春青[1] 王占敏[1] 钮伟芳[1] 

机构地区：[1]河北省荣军医院,保定071000

出　　处：《中国健康心理学杂志》2013年第8期1152-1153,共2页China Journal of Health Psychology

摘　　要：目的比较奥氮平合用氟西汀与单用氟西汀治疗难治性抑郁症的疗效和安全性。方法 72例难治性抑郁患者随机分为两组,研究组给予奥氮平合用氟西汀治疗,对照组给予氟西汀,疗程8周。采用汉密尔顿抑郁量表(HAMD)和治疗中出现的副反应量表(TESS)评定疗效及不良反应。结果治疗8周末两组HAMD评分均显著下降(t=6.712,7.491,P<0.01),研究组显效率高于对照组(t=5.007,P<0.05),两组不良反应均较轻微。结论奥氮平与氟西汀合用比单用氟西汀治疗难治性抑郁症疗效好,不良反应轻微。Objective To evaluate the efficacy and safety of olanzapine combined with fluoxetine versus fluoxetine in treatment of refractory depression.Methods A total of 72 depressive patients were randomly divided into research group which received olanzapine combined with fluoxetine and control group which received fluoxetine for 8 weeks.Curative effect was assessed using Hamilton depression scale（HAMD）.Adverse reactions was assessed with treatment emergent symptoms scale（TESS）.Results Two groups showed significant score decreases on HAMD（t=6.712,7.491;P0.01）,but the research group showed faster score drop on HAMD and higher effective rate than control group.There was no significant difference on TESS score between two groups（t=5.007,P0.05）.Conclusion Olanzapine combined with fluoxetine is effective and safe,and has better compliance in treatment of refractory depression.

关 键 词：奥氮平 氟西汀 抑郁症 不良反应 

分 类 号：R749.4[医药卫生—神经病学与精神病学]