肥大细胞与肿瘤血管生成  

Mast cells and tumor angiogenesis

作　　者：曹莉[1] 李维[1] 邓凡[1] 

机构地区：[1]南方医科大学细胞生物学教研室,广州510515

出　　处：《国际肿瘤学杂志》2013年第7期483-485,共3页Journal of International Oncology

基　　金：国家自然科学基金（30973014,81272852）

摘　　要：肥大细胞（MC）是起源于骨髓，定居于组织的免疫细胞。肿瘤可以通过干细胞因子（SCF）及其在肥大细胞上的受体c-kit来介导对MC的募集。MC在肿瘤部位的数量和分布与肿瘤的生长、血管新生密切相关。MC可以通过释放血管生成因子介导血管新生，促进肿瘤的进展。Mast cells （MCs） are bone marrow-derived and tissue-homing immune cells which have important functions. Recruitment and activation in tumors are demonstrated to be mainly mediated by tumor- derived stem cell factor （SCF） and its receptor c-kit on MCs. The numbers and distributions of MCs in tumors are closely related to the growth of tumors and angiogenesis. MCs can mediate angiogenesis by releasing a series of angiogenesis factors, so as to promote the progress of tumors.

关 键 词：肥大细胞 肿瘤 新生血管化 病理性 

分 类 号：R734.2[医药卫生—肿瘤]