乏氧及Notch1在多发性骨髓瘤中的作用  

Roles of hypoxia and Notchl in multiple myeloma

作　　者：李斑斑[1] 郭冬梅[1] 滕清良[1] 

机构地区：[1]山东省泰安市中心医院血液内科,271000

出　　处：《国际肿瘤学杂志》2013年第7期542-546,共5页Journal of International Oncology

基　　金：山东省自然科学基金（2009ZRA09006）;山东省医药卫生科技发展计划项目（2011HW077）

摘　　要：多发性骨髓瘤（MM）存在明显的骨髓乏氧微环境，骨髓高表达乏氧诱导因子-1α（HIF—1α），其与预后不良相关。Notch信号通路是造血微环境中调控细胞增殖与分化的重要信号转导系统，与多发性骨髓瘤的发生和耐药有关。新近研究显示乏氧与Notch通路在多种恶性肿瘤发生发展中存在密切联系。乏氧微环境、HIF-1α及Notch相关信号通路的相互作用为开拓MM分子靶向治疗提供理论依据。Recently numerous studies have demonstrated that Notch signaling pathway plays a critical role in regulating cell proliferation and differentiation in hematopoietic microenvironment, which is associated with MM occurrence and the drug resistance. The latest researches show that there are close relations between hypoxia and Notch signaling pathway in tumor occurrence and progression. Exploring the interactions of microenvironment of hypoxia, HIF-1α and Notch signaling pathway will provide theoretical basis for MM targeted therapy.

关 键 词：细胞低氧 缺氧诱导因子1 Α亚基 多发性骨髓瘤 受体 Notchl 

分 类 号：R733.3[医药卫生—肿瘤]