光化学诱导大鼠局灶脑缺血动物模型的建立及磁共振T_2WI检测  

Development of photochemistry induced local brain ischemia and magnetic resonance T_2WI examination in rats.

作　　者：张杰文[1] 索爱琴[1] 张茂悦[2] 童萼塘[2] 丁广良[3] 胡红兵[3] 李津蕊[3] 高克林[3] 李丽云[3] 

机构地区：[1]河南省人民医院神经内科 [2]同济医科大学附属协和医院 [3]中国科学院武汉物理所

出　　处：《华中医学杂志》2000年第4期179-180,F004,共3页Central China Medical Journal

基　　金：中国科学院武汉物理所资助课题!(No.9815 0 8)

摘　　要：目的　检测光化学诱导大鼠局灶脑缺血后 MRI改变。方法　给大鼠尾静脉注射孟加拉玫瑰红 ,经颅骨用黄色激光连续光束照射 ,T2 WI检测。结果　 1小时内即发现了缺血灶 ,图像清晰 ,部位明确。结论　 T2 WI是一种确定脑缺血早期改变的敏感的检测方法。Objective To examine the imaging changes of brain follwing local cerebral ischemia induced by photochemistry in the rat.Methods Rose bengal was injected through the tain vein.The brain was irradiated with yellow laser light through the intact skull.Magnetic resonance T 2WI was examined.Results Ischemic focus in brain was found within 1h after irradiation.The images and positions were clear.Conclusion T 2WI was a sensitive method to detect the early changes in brain ischemia.

关 键 词：光化学 磁共振T2WI 局灶性脑缺血 动物模型 

分 类 号：R743.3[医药卫生—神经病学与精神病学]