咬合力丧失对大鼠磨牙牙周膜bFGF表达的影响  

Effect of lost bite force on the expression of bFGF in rat molar periodontal ligament

作　　者：赵云凤[1] 刘飞[1] 李明哲[1] 李甘地[2] 

机构地区：[1]华西医科大学口腔医学院修复科,成都610041 [2]华西医科大学第一附属医院病理科

出　　处：《中华口腔医学杂志》2000年第5期353-355,I027,共4页Chinese Journal of Stomatology

基　　金：国家自然科学基金!资助项目 ( 3 9970 799)

摘　　要：目的　研究咬合力丧失后大鼠磨牙牙周膜 (periodontalligament,PDL)内碱性成纤维细胞生长因子 (basicfibroblastgrowthfactor,bFGF)表达的动态变化 ,结合其他实验结果初步探讨了bFGF与Ⅰ型胶原mRNA表达的关系。方法　采用拔牙法建立咬合力丧失的动物模型 ,应用免疫组织化学法研究其磨牙牙周膜内bFGF表达的动态变化。结果　在 1天、2天、3天、1周与 2周 ,咬合力丧失组与正常咬合力组相比 ,牙周膜内bFGF表达差异有显著性 (P <0 .0 5 ) ,3周后差异无显著性。结论　咬合力丧失时PDL内的bFGF表达增强。Objective To observe the dynamic change of the expression of basic fibroblast growth factor(bFGF) in rat molar periodontal ligament(PDL), combined with other experiments to probe into the relation of the expression between bFGF and typeⅠcollagen mRNA. Methods Animal model was established by extracting the left maxillary molars. Immunohistochemistry was applied.Results The expression of bFGF obviously increased from the first day to the second week ( P <0.05), Came back to that of normal bite force group at the third week. There were strong negative relative relationship between the expression of bFGF and that of type Ⅰcollagen mRNA.Conclusion The expression of bFGF increased under lost bite force in rat molar PDL. The effect of bite force on the expression of PDL typeⅠcollagen mRNA is closely related to the expression of bFGF.

关 键 词：咬合力丧失 牙周膜 磨牙 大鼠 BFGF表达 

分 类 号：R781.4[医药卫生—口腔医学]