文拉法辛缓释剂临床应用专家指导建议  

Expert consensus for clinical appliance of venlafaxine controlled release formulation

作　　者：吴文源[1] 黄继忠[2] 司天梅[3] 许秀峰[4] 梅其一[5] 季建林[6] 李惠春[7] 张宁[8] 陆峥[1] 施慎逊[9] 周东丰[3] 江开达[2] 赵靖平[10] 李凌江[10] 贾福军 王刚[12] 刘铁榜[13] 张明园[2] 

机构地区：[1]同济大学附属同济医院,上海200065 [2]上海交通大学附属精神卫生中心,上海200030 [3]北京大学精神卫生研究所,卫生部精神卫生学重点实验室(北京大学),北京100191 [4]昆明医科大学第一附属医院,昆明650032 [5]苏州市广济医院,江苏苏州215008 [6]复旦大学附属中山医院,上海200032 [7]浙江大学医学院附属第二医院,杭州310009 [8]南京脑科医院,南京210029 [9]复旦大学附属华山医院,上海200031 [10]中南大学湘雅二医院,长沙410011 [11]广东省精神卫生研究所,广州510120 [12]北京安定医院,北京100008 [13]深圳市精神卫生研究所,广东深圳518020

出　　处：《中国心理卫生杂志》2013年第7期550-560,共11页Chinese Mental Health Journal

摘　　要：文拉法辛(venlafaxine)是5-羟色胺和去甲肾上腺素再摄取抑制剂,在多个国家作为抑郁症或广泛性焦虑障碍防治指南推荐的一线治疗药物,对躯体化症状也有较好疗效.文拉法辛国内主要使用缓释胶囊等剂型,获批准适应证是各种类型抑郁症和广泛性焦虑障碍.文拉法辛具有相对独特的精神药理、药效、药代动力学特征,使用过程要注意一些事项.为进一步规范其临床应用以发挥最佳疗效,国内相关领域专家结合国内外抑郁症、焦虑障碍诊疗指南、循证医学证据和自身用药经验,撰写本文为临床医生提供科学用药的较全面信息,包括用药技巧、安全性、老年、儿童、孕妇和哺乳期患者等特殊人群中的临床应用等。Venlafaxine is one of substances of serotonin and noradrenaline reuptake inhibitors （SNRIs）, which is regarded as the first-line drug for depressive disorder and generalized anxiety disorder by several practice guidelines across the world, as well as an effective one for somatoform symptoms such as pain and others. The indications are authorized to any kind of depressive disorders and generalized anxiety disorder in China Compared by other formulations, controlled released one is most widely prescribed in China It is well-known that venlafaxine and its controlled released formulations show relatively special characters in its psychopharmacologies, pharmacody- namics, and pharmacokinetics. To further clarify applied strategy in achieving optimum effect of venlafaxine formulation during clinic, some national famous expects wrote the consensus based on the international practice guidelines in depressive disorder and anxiety disorder, evidence-based medicine combined by their own experiences. The expert consensus involved clinical effect evidence, strategy, safety concern in treating patients with depressive disorders, generalized anxiety disorder and related conditions. Application and cautions in special population of aged, childhood and adolescents, gestation and breast feeding is also discussed.

关 键 词：文拉法辛 焦虑 抑郁 治疗 

分 类 号：R749.405.3[医药卫生—神经病学与精神病学] R971.43[医药卫生—临床医学]