Expression and Significance of Prosaposin (PSAP) in A Rat Model of Letrozole-induced Polycystic Ovary Syndrome  

作　　者：Yuan-yuan FANG Yi-ning LI Ying-xin YE Xiu-xia WANG 

机构地区：[1]Department of Gynaecology and Obstetrics, Shengjing Hospital of China Medical University

出　　处：《Journal of Reproduction and Contraception》2013年第2期67-75,共9页生殖与避孕（英文版）

基　　金：a Colleges and Universities Scientific Program supported by Education Department of Liaoning Province (LT2010106)

摘　　要：Objective To investigate the prosaposin （PSAP） expression in polycystic ovaries. Methods The expression of PSAP was examined using immunohistochemistry, quantitative RT-PCR and Western blotting in a rat model with letrozole-induced polycystic ovary syndrom （PCOS）. Results Letrozole-induced PCOS rat models were similar to those in human PCOS in endocrine disturbances, metabolic characteristics and morphology features. And in these models both mRNA and protein levels of PSAP were significantly increased. Conclusion PSAP was overexpressed in the letrozole-induced PCOS rat model and might play an important role in the oceurance and development of PCOS.Objective To investigate the prosaposin （PSAP） expression in polycystic ovaries. Methods The expression of PSAP was examined using immunohistochemistry, quantitative RT-PCR and Western blotting in a rat model with letrozole-induced polycystic ovary syndrom （PCOS）. Results Letrozole-induced PCOS rat models were similar to those in human PCOS in endocrine disturbances, metabolic characteristics and morphology features. And in these models both mRNA and protein levels of PSAP were significantly increased. Conclusion PSAP was overexpressed in the letrozole-induced PCOS rat model and might play an important role in the oceurance and development of PCOS.

关 键 词：polycystic ovary syndrom （PSAP） PCOS rat model （PCOS） androgen receptor （AR） PROSAPOSIN 

分 类 号：R711.75[医药卫生—妇产科学]