PROSAPOSIN

作品数：8被引量：16H指数：3
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相关领域：医药卫生生物学更多>>
相关作者：周天鸿李月琴郭芬罗志文李弘剑更多>>
相关机构：暨南大学广东药学院复旦大学中国医科大学更多>>
相关期刊：《Neural Regeneration Research》《Signal Transduction and Targeted Therapy》《遗传》《暨南大学学报（自然科学与医学版）》更多>>
相关基金：广东省自然科学基金国家教育部博士点基金国家自然科学基金更多>>
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Prosaposin hyperglycosylation: a novel tumor immune escape mechanism and implications for cancer immunotherapy
《Signal Transduction and Targeted Therapy》2024年第8期3150-3152,共3页Matthias Peipp Diana Dudziak Christian Kellner 
In a recent article published in Science,Sharma et al.describes the essential role of saposins in cross-presentation of tumor membraneassociated antigens by dendritic cells(DC)to CD8^(+)T cells.1 However,antigen cross...
关键词：IMPAIRED IMMUNITY 
Expression and Significance of Prosaposin (PSAP) in A Rat Model of Letrozole-induced Polycystic Ovary Syndrome
《Journal of Reproduction and Contraception》2013年第2期67-75,共9页Yuan-yuan FANG Yi-ning LI Ying-xin YE Xiu-xia WANG 
a Colleges and Universities Scientific Program supported by Education Department of Liaoning Province (LT2010106)
Objective To investigate the prosaposin （PSAP） expression in polycystic ovaries. Methods The expression of PSAP was examined using immunohistochemistry, quantitative RT-PCR and Western blotting in a rat model with l...
关键词：polycystic ovary syndrom （PSAP） PCOS rat model （PCOS） androgen receptor （AR） PROSAPOSIN 
含外显子8的prosaposin蛋白亚型与Rhox5蛋白间的相互作用被引量：1
《暨南大学学报（自然科学与医学版）》2010年第3期307-311,共5页郭芬 李月琴 李实骞 罗志文 张欣 周天鸿 
广东省自然科学基金项目(8151063201000013);高等学校博士学科点专项科研基金项目(20060559006)
研究含外显子8的prosaposin蛋白亚型(PsapE8)与同源异型框蛋白Rhox5蛋白间的相互作用.重叠延伸PCR法扩增PsapE8的cDNA序列,将其按照通读框方式分别克隆至pGBKT7和pGADT7酵母双杂交载体中构建pGBKT7-PsapE8和pGADT7-PsapE8重组质粒.酵母...
关键词：含外显子8的prosaposin蛋白亚型(PsapE8) Rhox5蛋白 蛋白相互作用 
Prosaposin对细胞增殖和凋亡的调控及其分子机制被引量：4
《遗传》2009年第12期1226-1232,共7页郭芬 罗志文 刘兆宇 李月琴 李弘剑 周天鸿 
广东省自然科学基金项目(编号:8151063201000013);"211"工程经费项目资助
为研究鞘脂激活蛋白原(Prosaposin)对细胞增殖、细胞凋亡的调控及其可能的分子机制,以pcDNA3.1 in NIH3T3阴性对照细胞株和过表达prosaposin的Psap-Myc in NIH3T3细胞株为模型,噻唑蓝(MTT)比色法检测prosaposin对细胞增殖的影响;Annexi...
关键词：鞘脂激活蛋白原 细胞增殖 细胞凋亡 P13K/AKT信号通路 基因表达 
Altered prosaposin expression in the rat facial nerve nucleus following facial nerve transection and repair
《Neural Regeneration Research》2009年第3期230-235,共6页Dong Wang Wenlong Luo Cuiying Zhou Jingjing Li 
BACKGROUND： Studies have demonstrated that damaged facial nerves synthesize prosaposin to promote repair of facial neurons. OBJECTIVE： To observe time-course changes of prosaposin expression in the facial nerve nucl...
关键词：facial nucleus： orosaposin： rats： facial nerve 
Identification of Prosaposin as a Novel Interaction Partner for Rhox5
《Journal of Genetics and Genomics》2007年第5期392-399,共8页郭芬 黄晓锋 李实骞 孙丽敏 李月琴 李弘剑 邹奕 初彦辉 周天鸿 
This work was supported by the National Natural Sciences Foundation of China (No. 39770411) ;Doctoral Fund of Ministry of Education of China (No. 20060559006).
Prosaposin （Psap） has multiple cellular functions. It is involved in the development of the reproductive system, nervous system, and prostate cancer as well as in the regulation of sphingolipid catabolism by activat...
关键词：Rhox5 PROSAPOSIN functional interaction reproductive system 
Saposin C stimulates growth and invasion,activates p42/44 and SAPK/JNK signaling pathways of MAPK and upregulates uPA/uPAR expression in prostate cancer and stromal cells被引量：7
《Asian Journal of Andrology》2005年第2期147-158, ,共12页Shahriar Koochekpour Oliver Sartor Masao Hiraiwa Tae-Jin Lee Walter Rayford Natascha Remmel Konrad Sandhoff ArdalanMinokadeh DavidY.Patten 
Aim:To determine the effect of saposin C (a known trophic domain of prosaposin) on proliferation,migration and invasion,as well as its effect on the expression of urokinase plasmonogen activator (uPA),its receptor (uP...
关键词：saposin C prostate cancer UPA/UPAR PROSAPOSIN INVASION growth factor SAPK/JNK MAPK MMP c-Jun 
Prosaposin ablation inactivates the MAPK and Akt signaling pathways and interferes with the development of the prostate gland被引量：6
《Asian Journal of Andrology》2003年第1期57-63,共7页Carlos R.Morales Haitham Badran 
The recent development of a prosaposin -/- mouse model has allowed the investigation of the role of prosaposin in the development of the male reproductive organs. A morphometric analysis of the male reproduc...
关键词：mouse PROSTATE PROSAPOSIN mitogen activating phosphokinases (MAPKs) 
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