手针和电针足三里穴持续性效应的功能磁共振成像研究  

fMRI Investigation of the Sustained-effect of Manual Acupuncture and Electro-acupuncture

作　　者：谭建豪[1] 王燕燕[1] 隆晓菁[2] 刁彦君[2] 

机构地区：[1]湖南大学电气与信息工程学院,湖南长沙410082 [2]中科院深圳先进技术研究院,广东深圳510085

出　　处：《湖南大学学报（自然科学版）》2013年第7期64-68,共5页Journal of Hunan University:Natural Sciences

基　　金：国家自然科学基金重点项目(60634020)

摘　　要：通过采集的静息态脑功能磁共振成像数据和并对其进行分析,分别探索传统手针和电针足三里穴的人脑持续性效应的中枢神经系统活动.选择12例(6男,6女,23～27岁)无针刺经历的、右利手健康成年志愿者,分成手针组(12例)和电针组(12例).手针刺激(2Hz)和电针刺激(2Hz,连续方波,电流强度0.5～1.4mA)实验中,针刺刺激分别以2Hz的频率对足三里进行2min的双向捻转,采集针刺刺激前后静息态的数据进行预处理并对其进行统计分析.统计结果显示手针和电针针刺足三里后引起了不同的持续性效应,包括中脑和基底神经节在内的参与与镇痛有关的神经递质释放的脑区结构,在针刺刺激后阶段呈现出了持续性的活动.两种针刺模态下不同的脑区响应模式表明两者可能在经络传输通道和神经递质系统的活动存在差异.This paper investigated the sustained effect of central nervous system activities on human brain between traditional manual acupuncture and electro-acupuncture on ST-36 by collecting resting-state functional magnetic resonance imaging （fMRI） data and analyzing the fMRI data. 12 （male/female= 6/6, aged from 23 to 27） acupuncture naive, right-handed healthy adult volunteers were chosen and divided into manual acupuncture （MA） group （12 subjects） and electro-acupuncture （EA） group （12 subjects）. The needle was rotated bi-directionally at the frequency of 2 Hz for 2 minutes stimulation on ST-36 during MA （2 Hz） and EA （constant square wave, 2 Hz, intensities ranging from 0.5 to 1.4 mA）. Statistical results showed that manual acupuncture and electro-acupuncture induced different long-lasting responses after the administration of acupuncture on ST-36. Structures associated with the release of analgesia-related neuro- transmitters, including the midbrain and basal ganglia, presented prolonged activities in post-stimulusstage. Different patterns of brain responses between the two modalities may show differences in the trans- mission channels of meridian and activities in neurotransmitter system.

关 键 词：功能磁共振成像 持续性效应 手针 电针 

分 类 号：R445.2[医药卫生—影像医学与核医学] R245[医药卫生—诊断学]