Galectin-3和CD44v6的表达与前列腺癌转移及预后的关系  

Expression of Galectin-3 and CD44v6 protein in prostatic carcinoma and its metastasis and prognosis

作　　者：赵朋[1] 刘德祥[1] 于斌[1] 张庆皎[1] 田丁[1] 刘博[1] 马春磊[1] 胡海龙[2] 白铁男[2] 孙光[2] 

机构地区：[1]天津市第四中心医院泌尿外科,天津300140 [2]天津医科大学第二医院泌尿外科

出　　处：《临床泌尿外科杂志》2013年第8期610-612,615,共4页Journal of Clinical Urology

基　　金：天津市应用基础及前沿技术研究计划基金资助项目(编号09JCYBJC27800);天津市卫生局科技基金资助项目(编号09KZ90)

摘　　要：目的:探讨Galectin-3和CD44v6蛋白表达与前列腺癌(PCa)临床病理特征和预后的关系。方法:应用免疫组织化学技术检测45例PCa、25例PIN和20例BPH组织中Galectin-3和CD44v6蛋白表达,并结合肿瘤的病理学行为和临床随访资料进行分析。结果:在PCa组织中,Galectin-3和CD44v6阳性表达率分别为(82.2±59.5)%、(75.6±24.0)%,均显著高于PIN和BPH组织(P<0.05)。Galectin-3和CD44v6表达与肿瘤分化程度、周围淋巴结转移、远处转移、预后密切相关(P<0.05)。Galectin-3和CD44v6蛋白表达呈显著正相关(r=0.412,P=0.005)。结论:Galectin-3和CD44v6蛋白表达与PCa发生、转移和患者生存期密切相关,联合检测可以对PCa的发生、发展、预后及药物治疗提供重要依据。Objective： To investgate the expression of Galectin-3 and CD44v6 protein in prostatic carcinoma and their relationship with metastatsis and prognosis. Methods： Immunohistochemical staining was used to detect the expression of Galectin-3 and CD44v6 protein in 45 cases of prostatic carcinoma, 25 cases of PIN and 20 cases of BPH. The study was also combined with analysis of the pathological behavior and clinical follow-up survey of prostatic carcinoma. Results： The positive expression rate of Galectin-3 and CD44v6 was （82. 2% ± 59. 5%）, （75.6%±24.0%）, which was higher than that in PIN and BPH（ P 〈0.05）. The expression of Galectin-3 and CD44v6 was closely related to the degree of histological grade, metastasis of lymph node, distant metastasis and prognosis of patients （ P d0.05）. Positive correlation was found between Galectin-3 and CD44v6 proteion（ r = 0. 412, P =0. 005）. Conclusion： These data suggest that the expression of Galectin-3 and CD44v6 is closely related to carcinogenesis, metastasis and survival rate in prostatic carcinoma patients. The combined detection of Galectin 3 and CD44v6 proteins can be used to evaluate the incidence of prostate carcinoma development, prognosis, and provide an important basis for drug treatment.

关 键 词：前列腺癌 GALECTIN-3蛋白 CD44V6蛋白 

分 类 号：R737.25[医药卫生—肿瘤]