TGF-β1基因多态性与高级别宫颈上皮内瘤变易感性的关系  

Relationship of transforming growth factor-β1 polymorphisms and susceptibility of high grade cervical intraepithelial neoplasia

作　　者：缪娟 傅士龙 尤志学 周德兰 丁波 董一善 韩素萍 

机构地区：[1]南京医科大学第一附属医院妇产科,江苏省210029

出　　处：《江苏医药》2013年第15期1768-1771,共4页Jiangsu Medical Journal

基　　金：江苏省自然科学基金(BK2012878)

摘　　要：目的研究转化生长因子β1(TGF-β1)基因多态性与高级别宫颈上皮内瘤变(CINⅡ-Ⅲ)遗传易感性的关系。方法选择191例CINⅡ-Ⅲ患者为病例组,207例年龄相匹配的正常者为对照组,采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)技术检测TGF-β1基因C509T和T869C多态性在两组中的频率和分布,比较不同基因型携带者患CINⅡ-Ⅲ的危险性。结果与携带T869CTT基因型相比,携带T869CTC/CC基因型者罹患CINⅡ-Ⅲ的风险升高1.582倍(OR=1.582,95%CI=1.026-2.438,P<0.05)。产次0-1次和不吸烟的女性携带T869CTC/CC基因型较携带TT基因型者罹患CINⅡ-Ⅲ的风险升高更为显著(P<0.05)。结论 TGF-β1T869C多态性可能与人群CINⅡ-Ⅲ的遗传易感性相关。Objective To evaluate the association of transforming growth factor-β1（TGF-β1） polymorphisms and risk for high grade cervical intraepithelial neoplasia（CINⅡ-Ⅲ）.Methods With polymerase chain reaction-restriction fragment length polymorphism（PCR-RFLP）method,TGF-β1 C509Tand TGF-β1 T869Cpolymorphisms were detected and the risk factors for CINⅡ-Ⅲ were compared in 191women with CINⅡ-Ⅲ（group A）and 207controls（group C）.Results The risk for CINⅡ-Ⅲin the cases carrying T869CTC/CC genotypes was 1.582times more than those carrying TT genotype（OR=1.582,95%CI=1.026-2.438,P〈0.05）.The risk for CINⅡ-Ⅲ in women carrying TC/CC genotypes was even more pronounced with parity ≤1and nonsmoker.Conclusion The TGF-β1 T869C polymorphism may contribute to the susceptibility of high grade cervical intraepithelial neoplasia.

关 键 词：转化生长因子Β1 高级别宫颈上皮内瘤变 单核苷酸多态性 

分 类 号：R737[医药卫生—肿瘤]