基于对称导联EEG特征分析的脑损伤部位判别  

Localization of brain injuries in vegetative and minimally conscious patients using symmetric electrode EEG analysis

作　　者：李轶[1] 赵波[1] 杨文伟[1] 李景琦 徐伟栋[1] 徐莹[1] 沈蔡娴[1] 厉力华[1] 杨勇[1] 

机构地区：[1]杭州电子科技大学生命信息与仪器工程学院,杭州310018 [2]浙江省武警医院康复中心,杭州314000

出　　处：《科学通报》2013年第21期2087-2093,共7页Chinese Science Bulletin

基　　金：国家自然科学基金(30770685);国家重点基础研究发展计划(2013CB329502);浙江省自然科学基金(LY12F03003)资助

摘　　要：提出了一种基于对称导联的脑电(EEG)分析方法,以探讨脑电特征和脑损伤部位之间的对应关系,实现损伤部位的判别.研究样本由脑损伤导致的严重意识障碍患者25例(其中左侧损伤11人,右侧损伤14人)和对照组正常人8例组成.首先,提取安静状态下的脑电信号低频段(δ+θ)和高频段(α+β)的功率谱比值和近似熵2种特征参数,并分别计算对称导联的EEG特征参数的比值;然后,分析不同对称脑区的特征参数比值,基于此特征参数比值对损伤部位进行判别;最后将判别结果同CT图像诊断结果进行匹配对比.结果表明,严重意识障碍患者的脑损伤和未损伤部位对称电联之间脑电特征参数比值具有显著性的差异(P<0.05),基于对称导联EEG特征分析的脑损伤部位判别结果和基于病例CT图像的诊断结果相吻合.因此,基于对称导联的EEG分析法能够简便可靠地实现脑损伤部位的判别,在脑功能研究和临床辅助诊断中有一定的应用推广价值.We propose a new method of EEG analysis for identifying brain injuries. Specifically, we used symmetric electrode patterns to investigate correlations between characteristic EEG parameters and brain injured areas. Twenty-five subjects （11 patients with injuries in the left hemisphere and 14 patients with injuries in the right hemisphere） in vegetative and minimally conscious states resulting from＇ traumatic brain injury were involved in the study, along with 8 healthy controls. First, we examined the power spectral ratio of the low-frequency （c~＋0） and high-frequency （a＋fl） bands, as well as the approximate entropy of each subject＇s EEG in a quiet state. This was done to calculate the characteristic parameter ratios of the symmetric electrodes. Second, the characteristic parameter ratios of different brain areas were quantitatively analyzed to identify the brain injured areas. Finally, the identification results were compared to CT images. Results indicated that the characteristic parameter ratios between injured and uninjured brain areas were significantly different （P〈0.05）, and that the brain injured areas identified by our EEG analysis method were consistent with that of the CT data. Thus, we suggest that our proposed method has great clinical potential for the convenient and reliable identification of brain injuries.

关 键 词：脑电波 严重意识障碍 脑损伤 对称导联 

分 类 号：R318.0[医药卫生—生物医学工程]