术前外周血中性粒细胞／淋巴细胞比值在结直肠癌预后评估中的价值  

Assessment value of preoperative neutrophil-lymphocyte ratio for the prognosis of patients with colorectal cancer after radical operation

作　　者：刘海亮[1] 杜晓辉[2] 孙培鸣[1] 肖春红[1] 邹振玉[1] 徐迎新[1] 

机构地区：[1]解放军总医院普通外科解放军总医院普通外科研究所,北京100853 [2]解放军总医院海南分院普通外科

出　　处：《中华胃肠外科杂志》2013年第8期723-726,共4页Chinese Journal of Gastrointestinal Surgery

摘　　要：目的探讨术前外周血中性粒细胞／淋巴细胞比值（NLR）对结直肠癌患者预后评估的价值。方法回顾性分析2005年7月至2011年7月问在解放军总医院普通外科接受根治性手术且术后随访资料完整的140例结直肠癌患者的临床资料。根据患者术前外周血NLR分为低NLR组（小于5，105例）和高NLR组（大于或等于5，35例），比较两组患者的术后5年生存率并进行预后分析。结果低NLR组和高NLR组结直肠癌患者术后5年生存率分别为74-8％和54．7％，差异有统计学意义（P=0．03）。单因素分析显示，术前NLR、肿瘤位置、浸润深度、淋巴结转移及肿瘤分期与本组患者术后生存有关（P〈0．05和P〈0．01）；多凶素预后分析证实，NLR是影响本组结直肠癌患者预后的独立危险因素（RR=I．068，95％c1：1．009～1．129，P=0．02）。结论术前NLR大于或等于5提示结直肠癌患者预后较差。Objective To assess the value of preoperative neutrophil-lymphocyte ratio（NLR） for prognosis in patients with colorectal cancer after radical operation. Methods Clinical data of 140 patients with colorectal cancer undergoing radical operation in the Department of General Surgery of General Hospital of PLA from July 2005 to July 2011 were analyzed retrospectively. According to preoperative NLR, patients were divided into the low NLR group（NLR〈5, n=105） and the high NLR group （NLR~〉5, n=35）. The overall 5-year survival rates of two groups were compared and the independent risk factors were examined by univariate analysis and Cox model. Results The overall 5-year survival rates of the low and high NLR groups were 74.8% and 54.7% respectively with significant differencre （P=0.03）. Univariate analysis revealed depth of tumor, lymph nodes metastasis, TMN stage and NLR were associated with survival（P〈0.05, P〈0.01）. C model showed that NLR was independent risk factor of prognosis （RR = 1.068, 95 % CI： 1.009-1.129, P=0.02）. Conclusion Preoperative NLRt〉5 predicts poorer prognosis of colorectal cancer patients.

关 键 词：结直肠肿瘤 中性粒细胞 淋巴细胞比值 预后 

分 类 号：R735.3[医药卫生—肿瘤]