基于^18F—FDGPET显像建立帕金森病脑代谢网络模式  

Metabolic brain networks in patients with Parkinson＇s disease based on ^18F-FDG PET imaging

作　　者：吴平[1] 林春颖[3] 张慧玮[1] 赵简[2] 黄喆慜[1] 管一晖[1] 王坚[2] 左传涛[1] 

机构地区：[1]复旦大学附属华山医院PET中心,上海200235 [2]复旦大学附属华山医院神经内科,上海200235 [3]复旦大学附属华山医院南汇分院、上海市浦东新区南汇中心医院

出　　处：《中华核医学与分子影像杂志》2013年第4期275-278,共4页Chinese Journal of Nuclear Medicine and Molecular Imaging

基　　金：国家自然科学基金（81171189）;上海市科学技术委员会科研计划（09411960900）;上海市卫生局科研课题（2010116）

摘　　要：目的在PD患者中建立疾病相关脑代谢网络模式（PDRP），为PD早期诊断和鉴别诊断奠定基础。方法对32例不同严重程度的PD患者和32名年龄、性别匹配的健康对照者分别行静息状态下^18F—FDGPET脑显像，将2组的PET图像进行主成分分析（PCA）以获得PDRP。观察PDRP表达值与疾病严重程度[PD综合评分量表（UPDRS）运动功能评分和Hoehn＆Yahr评分]之间的相关性。统计学比较采用两样本t检验和Pearson相关分析。结果PDRP的特征表现为脑内壳核、苍白球、丘脑、脑桥、小脑和初级运动皮质的葡萄糖代谢增高，而运动前区和后顶叶的代谢相对减低。PD组的PDRP表达值明显高于对照组（1．605±0．655与0．000±0．523；t=10．829，P〈0．001），且与UPDRS运动功能评分呈明显正相关（r=0．760，P〈0．001）。PDRP表达值与Hoehn＆Yahr评分之间亦存在明显正相关（r=0．736，P〈0．001）。结论基于^18F—FDGPET显像得到的PDRP可以有效区分PD患者和健康对照者．并反映病情的严重程序。Objective To validate PD-related pattern （PDRP） network as a measure of PD by ~SF- FDG PET imaging. Methods Thirty-two PD patients with different severities and 32 healthy controls matched by age and gender were recruited in studies of resting-state brain 1SF-FDG PET imaging. To obtain the PDRP, principal component analysis （PCA） was used. The correlations between PDRP expression and the severities of PD （ classified by unified PD rating scale （UPDRS） motor scores and Hoehn ＆ Yahr sta- ges ） were investigated. The two-sample t test and Pearson correlation analysis were used for statistical analy- sis. Results PDRP was characterized by relative metabolic increases in the putamen, globus pallidus （GP） , thalamus, pans, cerebellum and primary motor cortex, and was associated with decreases in the premotor and posterior parietal areas. The value of PDRP expression in PD group （ 1.605±0.655 ） was sig- nificantly higher than that of healthy controls （0.000±0.523; t = 10.829, P〈0.001 ）. The value of PDRP ex- pression also correlated significantly with UPDRS motor scores （r= 0.760, P〈0.001 ） and Hoehn ＆ Yahr stages in PD group （r=0. 736, P〈0.001）. Condusion The PDRP based on lSF-FDG PET imaging can be useful for identification of PD patients from healthy controls and correlates well with the severity of the disease.

关 键 词：帕金森病 脑 代谢 体层摄影术 发射型计算机 脱氧葡萄糖 

分 类 号：R742.5[医药卫生—神经病学与精神病学]