Z-DNA的形成及其与基因转录的关系  

Z-DNA Formation and Its Link with Gene Transcription

作　　者：黄胜和[1,2] 吴初新[3] 李东明[1] 饶泽昌[1] 胡成钰[2] 

机构地区：[1]南昌大学抚州医学分院,江西抚州344000 [2]南昌大学生命科学与食品工程学院,南昌330031 [3]南昌师范高等专科学校,南昌330103

出　　处：《中国生物化学与分子生物学报》2013年第8期699-703,共5页Chinese Journal of Biochemistry and Molecular Biology

基　　金：国家自然科学基金资助项目(No.30860218)~~

摘　　要：Z-DNA是一种非常独特的DNA二级结构.与B-DNA相比,Z-DNA最显著的结构特征是左手螺旋和磷酸-核糖骨架呈"zigzag"状.虽然目前对Z-DNA功能的了解还不确切,但毫无疑问,Z-DNA与基因的转录和调控密切相关.一方面,在体内Z-DNA在基因转录过程中产生;另一方面,分布于启动子等不同区域的Z-DNA又可以反过来调控基因的转录,即Z-DNA能够增强一些基因转录,也能抑制某些基因的表达,但其调控机制还不清楚.这种调控似乎与Z-DNA在启动子中的位置、基因和细胞类型有关.研究Z-DNA的形成及其与基因转录的关系对理解基因转录调控理论具有十分重要的意义.Z-DNA is a special secondary structure of DNA. Different from B-DNA, Z-DNA is a left-handed helical conformation in which the double helix winds in a zigzag pattern. Increasing evidence revealed that Z-DNA closely related to gene transcription and gene regulation. The formation of Z-DNA can be induced during gene transcription. The scattering of Z-DNA in different regions of a promoter could change the gene transcription. Therefore, Z-DNA is able to enhance or repress gene transcription, however with unclear mechanism. The positional effect of Z-DNA in the promoters in context of different genes or cells can be versatile. The knowledge about the relationship between Z-DNA and gene regulation is an important aspect for us to further understand the process of gene transcription.

关 键 词：Z-DNA 基因转录 启动子 基因调控 

分 类 号：Q751[生物学—分子生物学]