人工肝支持系统的现状和发展  

Current status and prospect of artificial liver support system

作　　者：姜楠[1] 王建锋[1] 韩炜[1] 李伟民[1] 窦科峰[1] 

机构地区：[1]第四军医大学西京医院肝胆胰脾外科,西安710032

出　　处：《中华消化外科杂志》2013年第8期637-640,共4页Chinese Journal of Digestive Surgery

基　　金：国家高技术研究发展计划项目（2012AA021005）

摘　　要：肝移植是治疗终末期肝病的最佳选择，但因供肝来源严重短缺，大多数患者在等待供肝过程中死亡，而人工肝支持系统辅助治疗可在短期内改善肝功能，在患者肝移植前起到桥梁作用。人工肝支持系统辅助治疗可替代肝脏的部分生物合成、解毒和代谢等功能，稳定各项生理生化功能，减轻肝脏负担，为肝移植做好准备。随着人工肝支持系统的广泛应用，新型人工肝支持系统不断问世，并逐步克服旧系统的不足以更好地满足临床需求，但是不可避免地存在各自的缺点。笔者就人工肝支持系统的优缺点、临床应用以及存在问题进行综述，为人工肝支持系统在治疗终末期肝病中的应用提供参考。Liver transplantation is the best treatment for end-stage liver disease. Because of the severe shortage of donor sources, most of the patients died while waiting for liver grafts. Artificial liver support system can improve the liver func- tion in a short time, and help patients to pass the waiting periods. Artificial liver support system takes place of composition, detoxi- fication and metabolism function of liver, stabilizes the physio- logical and biochemical index of liver, relieves the burden of liver and helps patients to prepare for the liver transplantation. With the wide application of artificial liver support system, new types of the artificial liver support systems gradually conquered the defects of the old types, but they still have their own defects. This review concludes the merits and demerits of artificial liver systems, its clinical application and the problems so as to help the treatment of end-stage liver disease.

关 键 词：肝衰竭 人工肝支持系统 

分 类 号：R575.3[医药卫生—消化系统]