姜黄素对变形链球菌UA159生长、粘附的体外实验研究  

Experimental research on Curcumin influencing Streptococcus mutans UA159 growth and adherence in vitro

作　　者：张碧楚 黄平[1] 胡萍[1] 陈卫民[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院口腔医学中心,湖北武汉430030

出　　处：《临床口腔医学杂志》2013年第8期469-471,共3页Journal of Clinical Stomatology

基　　金：国家自然科学青年基金资助(81000426)

摘　　要：目的:探索姜黄素对变形链球菌UA159的抗菌能力及姜黄素对变形链球菌UA159生物膜形成的影响。方法:微量肉汤稀释法检测姜黄素对变形链球菌的最低抑菌浓度(MIC)。分光光度计分析在抑菌浓度范围内姜黄素对变形链球菌生物膜形成的变化。结果:MIC法测得的姜黄素对变形链球菌的抑菌浓度为128μM,而15μM姜黄素即可显示出抑制变形链球菌生物膜形成的特性,且随着姜黄素浓度增加,抑制能力加强。结论:姜黄素具有抑制变形链球菌生物膜形成的特性,且该抑制能力不是建立在抑制变形链球菌生长基础上的。姜黄素可能成为龋病防治的新试剂。Objective：In this study,we analyzed the characteristic of the curcumin on the S. mutarts activity and discov- ered if curcumin influences the S. mutans biofilm formation. Method：Broth dilution method was used to detect the minimum inhibitory concentration（MIC）. The curcumin on the S. mutans UAI59 biofilm formation was determined by spectrophotome- ter analysis within the inbitory concentration. Result：Cureumin exerted inhibitory activity with MIC of 128 μM. Curcumin（15 txM） was found to reduce S. mutans biofilm formation and the inhibitory activity enhanced in a dose-dependent manner. Conclusion：The inhibitory effect of curcumin on S. mutans UA159 biofilm formation occurred below the MIC of curcumin for S. mutans. Curcumin represented as a promising anti-caries agent.

关 键 词：变形链球菌 姜黄素 最低抑菌浓度 生物膜 

分 类 号：R780.2[医药卫生—口腔医学]