地塞米松治疗慢性乙型肝炎重度患者的疗效观察  

Effect of dexamethasone on patients with severe type of chronic viral hepatitis B

作　　者：周清霞[1] 李志杰[1] 

机构地区：[1]南方医科大学附属新会医院肝病科,广东新会529100

出　　处：《中国医药科学》2013年第16期57-58,87,共3页China Medicine And Pharmacy

摘　　要：目的观察地塞米松对慢性乙型肝炎重度患者的疗效。方法将坚持随访的120例患者分为观察组及对照组,对照组予保肝、抗炎对症支持等综合治疗;观察组在对照组基础上加用地塞米松10mg冲击治疗3d,疗程3周。结果(1)进展至重型肝炎百分率:对照组有2例患者进展至重型肝炎者,占3.33%;观察组无患者进展至重型肝炎,两组进展率差异有统计学意义(P<0.05);(2)ALT含量比较:治疗前两组患者ALT比较无显著性差异,观察组治疗后3d、1周、2周及3周的ALT均显著低于对照组(P<0.05);(3)消化道症状改善例数比较:观察组患者在治疗3d、1周、2周的消化道症状改善例数均明显多于对照组(P<0.05);(4)不良反应比较:对照组未见明显不良反应,观察组有1例出现胃痛症状,两组发生率差异无统计学意义(P>0.05);(5)住院日:观察组住院日为(12.7±5.5)d,对照组为(17.1±7.8)d,两组住院日差异有统计学意义(P<0.05)。结论慢性乙型肝炎重度患者短期应用地塞米松冲击治疗,可快速改善病情,减少重型肝炎的发生且副作用少,且有助于缩短住院时间。Objective To observe the effect of dexamethasone on the patients with severe type of chronic viral hepatitis B. Methods 120 patients were divided into observation group and control group, control group to protect liver, anti-inflammatory, yellow suit the back support, etc. Comprehensive treatment; Based on the observation group in the control group with dexamethasone 10mg shock therapy 3 days, treatment for 3 weeks. Results （1） The percentage progress to severe hepatitis： the control group 2 patients progress to severe hepatitis, 3.33%; Observation group no patients progress to severe hepatitis, progress rate is similar between the two groups was statistically significant （P 〈 0.05）; （2）ALT content comparison： ALT to compare two groups of patients before treatment there was no significant difference, observation group after treatment for 3 days, 1 week, 2 weeks and 3 weeks of ALT were significantly lower than the control group （P 〈 0.05）; （3） the digestive tract symptoms improved cases comparison： observation group of patients in the treatment of 3 days, 1 week, 2 weeks and 3 weeks of the digestive tract symptoms improved cases were significantly more than control group（P 〈 0.05）;（4） adverse reactions： the control group did not see obvious adverse reaction, observation group have stomachache in 1 case, two groups had no statistical difference （P 〉 0.05）; （5） such confinement： the observation group was （12.7 ± 5.5） days of such confinement, the control group was （17.1 ± 7.8） days, such confinement similar between the two groups have statistical significance（P〈 0.05）. Conclusion Patients with chronic hepatitis B of severe impact short-term application of dexamethasone treatment,can quickly improve symptoms, reduce the occurrence of severe hepatitis and less side effects, and help to shorten the length of time.

关 键 词：慢性乙型肝炎 糖皮质激素 地塞米松 

分 类 号：R575.1[医药卫生—消化系统]