上皮性卵巢癌组织中MMP-2、COX-2基因表达的临床研究  

Clinical significance of MMP-2 and COX-2 expression in epithelial ovarian cancers

作　　者：李硕[1] 梅晶晶[2] 

机构地区：[1]皖南医学院附属弋矶山医院妇产科,安徽芜湖241001 [2]皖南医学院附属弋矶山医院病理科,安徽芜湖241001

出　　处：《皖南医学院学报》2013年第4期283-286,共4页Journal of Wannan Medical College

摘　　要：目的:探讨MMP-2蛋白和COX-2蛋白在上皮性卵巢癌组织中的表达及其临床意义。方法:采用免疫组织化学技术分别对上皮性卵巢癌组织和良性卵巢肿瘤组织中的MMP-2蛋白和COX-2蛋白的表达进行检测。结果:MMP-2蛋白和COX-2蛋白在20例良性卵巢肿瘤组织中不表达。在50例上皮性卵巢癌组织中,MMP-2蛋白和COX-2蛋白呈阳性表达,其表达率与良性卵巢肿瘤组织比较有差异(P<0.05),MMP-2蛋白和COX-2蛋白的阳性表达率与临床分期之间的差异有统计学意义(P<0.05)。MMP-2蛋白和COX-2蛋白的表达率与上皮性卵巢癌的分化程度和局部淋巴结是否转移有统计学差异(P<0.05)。结论:MMP-2蛋白和COX-2蛋白的表达与上皮性卵巢癌组织的发生发展有一定关系,可作为预后评估的一项参考指标。Objective： To assess the clinical significance of protein MMP2 and COX-2 expression in epithelial ovarian cancers.Methods： Immunohistochemical technique was used to detect the proteins of COX-2 and MMP-2 respectively expressed in specimens from epithelial ovarian cancer and benign ovarian tumors.Results： Both COX-2 and MMP-2 were not detected in the tissues of ovarian benign tumors,yet were positively expressed in 50 cases of epithelial ovarian cancer,which was statistically different（P ＆lt; 0.05）.Also,COX-2 was different from MMP-2 regarding the expression rate,clinical staging,degree of differentiation and presence or absence of regional nodal metastasis of the malignancy（P ＆lt; 0.05）.Conclusion： The generation and development of the epithelial ovarian cancer are associated with the expression of COX-2 and MMP-2 protein that may serve as an indicator for estimation of the prognosis of epithelial ovarian cancer.

关 键 词：上皮性卵巢癌组织 MMP-2蛋白 COX-2蛋白 免疫组织化学 

分 类 号：R737.31[医药卫生—肿瘤]