小檗碱治疗非酒精性脂肪性肝病的综合性护理干预  

COMPREHESIVE NURSING INTERVENTION OF BERBERINE TREATMENT OF NONALCHOHOLIC FATTY LIVER DISEASE

作　　者：彭雅莲[1] 刘丽娜[1] 徐晓明[1] 王红[1] 李梅[1] 李雯月[1] 陈家云[1] 

机构地区：[1]广东省第二人民医院,广东广州510317

出　　处：《现代医院》2013年第8期101-103,共3页Modern Hospitals

基　　金：广东省中医药局管理基金(编号:2012360YZH020242)

摘　　要：目的探讨小檗碱治疗非酒精性脂肪性肝病的护理干预效果。方法对2010年7月-2012年12月入住我院消化内科的126例非酒精性脂肪性肝随机分为观察组与对照组各63例，均服用小檗碱0．5克／次，3次／天，连续治疗16W，其中，对照组实施常规护理，观察组在常规护理的基础上实施个性化的饮食护理、生活调护、运动护理等综合性护理干预措施；观察护理前后血脂各项指标包括总胆固醇（TC）、低密度脂蛋白胆固醇（LDL—C）、高密度脂蛋白胆固醇（HDL—C）、甘油三酯（TG），且行B超检查脂肪肝程度，BMI指数，测定肝、肾功能，包括ALT、AST、GGT、Tbil、BUN、Cr。结果经过综合性护理后，与对照组相比，观察组TC、TG、LDL—c指标均显著下降，差异有统计学意义，P〈0．01，HDL—C指标无显著性差异，P〉0．05；行B超检查，观察组脂肪肝程度显著改善，P〈0．01；BMI指数略有下降，差异无统计学意义，P〉0．05；肝功能ALT、AST、GGT、Tbil指标均显著下降，差异有统计学意义，P〈0．01，肾功能BUN、Cr指标无显著性差异，P〉0．05。结论小檗碱治疗非酒精性脂肪性肝病疗效显著，配合综合性护理效果更佳。Objective To investigate the effect of nursing intervention of berberine treatment of nonalcoholic fatty liver disease. Methods In our hospital 2010 July - 2012 December in digestion Department of internal medicine 126 patients with nonalcoholic fatty liver were randomly divided into observation group and control group, each with 63 cases, all used berberine 0. 5 grams/time, 3 times per day, continuous treatment of 16 w. Patients in the control group received the routine nursing; in observation group patients implemented personalized diet nursing, life style care, and exercise care on the basis of routine nursing. Observe before and after implementation of nursing care the indicators of blood lipid include the plasma levels of total cholesterol（ TC）, low density lipoprotein cholesterol（ LDL - C ）, high density lipoprotein cholesterol（ HDL-C）, triglyceride（ TG）, B ultrasound examination of the degree of fat-ty liver, BMI index, determination of liver and renal functions, including ALT, AST, GGT, Tbil, BUN, Cr. Results After comprehensive care, compared with the control group, TC, TG, LDL - C were significantly decreased, the difference was statistically significant, p 〈 0. 01, there was no significant difference in HDL - C index, p 〉 0. 05 ; B ultrasound was performed in the observation group, the degree of fatty liver is improved significantly, p 〈 0. 01 ; BMI index declined slightly, difference had no statistical significance, p 〉 0. 05; liver function ALT, AST, GGT, Tbil were significantly decreased, the difference was statistically significant, p 〈 0. 01, renal BUN, Cr index of no signifi- cant difference, p 〉 0.05. Conclusion Berberine is significantly effective in treatment of nonalcoholic fatty liver dis-ease, and it is more excellent with better comprehensive nursing.

关 键 词：小檗碱 非酒精性脂肪性肝病 综合性护理 

分 类 号：R575.5[医药卫生—消化系统]